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EXercise-induced PhysioLogical Adaptations In Neurological Disorders

Sponsor: Brigham and Women's Hospital • ClinicalTrials.gov ID: NCT07883720

Registry updated: 2026-10-20

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Description

The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers. The main questions the study aims to answer are: * How do fitness level, exercise performance, and physical exhaustion differ between patients with neurological diseases and healthy participants? * How does acute exercise affect brain function and other physiological biomarkers in participants with neurological diseases? Participants will take part in a single, one-day study visit and will be asked to: * Perform a standardized exercise test on a bicycle ergometer * Undergo a brain MRI (magnetic resonance imaging) scan, a blood draw, and autonomic measurements before and after the exercise test

Interventions

Acute Exercise (Behavioral)
Cardiopulmonary exercise testing (CPET) will be performed on a bicycle ergometer using a standardized incremental ramp protocol until maximal voluntary exhaustion.

Eligibility criteria

Inclusion Criteria: * 18 years or older * Clinical diagnosis of one of the following neurological diseases: epilepsy, functional neurological disorder, mild cognitive impairment, dementia, Parkinson's disease, concussion, brain tumor \[for participants with neurological diseases\] * No diagnosis of neurological disease \[for healthy control participants\] Exclusion Criteria: * Non-english speaking individuals * Exercise contraindications (e.g., physical impairments limiting use of bicycle ergometer, acute infections, severe heart disease, uncontrolled hypertension, exercise associated seizures) * Current use of medications for cardiac rhythm or rate control * Magnetic resonance imaging (MRI) contraindications (e.g., electrical implants, ferromagnetic implants or objects, pregnancy)

Conditions

Epilepsy Functional Neurological Disorder Mild Cognitive Impairment Dementia Parkinson Disease Concussion, Brain Brain Tumor Healthy

Locations

Brigham and Women's Hospital — Boston, Massachusetts, United States

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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