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RECRUITING Not applicable ClinicalTrials.gov

Modified Thoracolumbar Interfascial Plane Block vs Retrolaminar Block for Pain in Lumbar Spine Surgeries

Sponsor: Zagazig University • ClinicalTrials.gov ID: NCT07883616

Registry updated: 2026-10-20
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Description

This prospective randomized double-blind study aims to compare the efficacy of modified Thoracolumbar Interfascial Plane (mTLIP) block versus Retrolaminar block for postoperative pain control in patients undergoing elective two-level lumbar spine surgeries. The primary outcome is total morphine consumption in the first 24 postoperative hours.

Interventions

  • Morphine (Drug)
    Rescue analgesic administered intravenously at a dose of 0.1-0.2 mg/kg every 2-4 hours as needed for breakthrough pain (NRS \> 3), with a maximum dose of 10 mg per administration.
  • Bupivacaine (Drug)
    Local anesthetic used in the block solution (0.25%, 15 mL per side).
  • Dexamethasone (Drug)
    Adjuvant added to the block solution (8 mg per side) to prolong analgesia.
  • Magnesium Sulphate (Drug)
    Adjuvant added to the block solution (300 mg of 10% per side) to prolong analgesia.
  • Modified Thoracolumbar Interfascial Plane Block (Procedure)
    Ultrasound-guided injection between the longissimus and iliocostalis muscles at the L3 level.
  • Retrolaminar Block (Procedure)
    Ultrasound-guided injection on the posterior surface of the vertebral lamina at the L3 level, deep to the erector spinae muscles.

Eligibility criteria

Inclusion Criteria: * Age between 21 and 65 years * ASA physical status I or II * BMI \< 30 kg/m² * Scheduled for elective two-level lumbar spine surgery (discectomy/decompression) * Expected duration of surgery less than 3 hours * Patient's acceptance and written informed consent Exclusion Criteria: * Infection at block site * Known allergy to used drugs * Coagulation disorder * History of psychiatric illness * Pre-existing neurological deficits * Presence of any metastasis * Previous lumbar spine surgeries * Patients on previous opioid therapy

Conditions

Postoperative Pain After Spinal Surgery

Locations

  • Zagazig University Hospitals, Anesthesia, Intensive Care and Pain Management Department — Zagazig, Sharqia Province, Egypt
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record