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RECRUITING Not applicable ClinicalTrials.gov

Role of HFNC During FOB in Patients With Respiratory Failure

Sponsor: Mansoura University • ClinicalTrials.gov ID: NCT07880964

Registry updated: 2026-10-19
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Description

This prospective interventional study aims to evaluate the safety and efficacy of high-flow nasal cannula (HFNC) oxygen therapy during fiber-optic bronchoscopy in patients with respiratory failure. The study will assess oxygenation, ventilation, , procedural interruptions, adverse events, patient comfort, and clinical outcomes during and after bronchoscopy.

Interventions

  • High flow nasal canula (Device)
    High-flow nasal cannula (HFNC) oxygen therapy will be administered using the Vapotherm Precision Flow Hi-VNI system. HFNC will be initiated approximately 10 minutes before fiber-optic bronchoscopy, maintained throughout the procedure, and continued for 1-2 hours after the procedure. The initial flow rate will be 40 L/min and may be adjusted between 10 and 40 L/min according to clinical requirements. FiO2 will be titrated to maintain the predefined oxygen saturation target (SpO2 ≥95% in most patients and 88-92% in patients with type 2 respiratory failure). Gas temperature will be set at approximately 34°C with 100% relative humidity. Continuous monitoring of SpO2, heart rate, respiratory rate, and blood pressure will be performed during the procedure, with additional arterial blood gas and end-tidal CO2 assessment according to the study protocol.

Eligibility criteria

Inclusion Criteria: Participants will be eligible for inclusion if they meet all of the following criteria: 1. Adult patients undergoing clinically indicated fiber-optic bronchoscopy. 2. Patients with respiratory failure requiring supplemental oxygen or respiratory support. 3. Patients who provide written informed consent to participate in the study. Exclusion Criteria: * Participants will be excluded if they meet any of the following criteria: 1. Patients requiring immediate endotracheal intubation or invasive mechanical ventilation before bronchoscopy. 2. Patients with severe or refractory hypoxemia despite maximal non-invasive oxygen/respiratory support before the procedure. 3. Hemodynamic instability that precludes safe fiber-optic bronchoscopy. 4. Patients with contraindications to fiber-optic bronchoscopy or to the planned bronchoscopy procedure. 5. Patients who refuse or withdraw informed consent. 6. Patients in whom HFNC cannot be safely applied or tolerated.

Conditions

Respiratory Failure Respiratory Failure With Hypercapnia

Locations

  • Faculty of Medicine, Mansoura University — Al Mansurah, Dakahlia Governorate, Egypt
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record