RECRUITING Phase 2 ClinicalTrials.gov

Full-thickness Versus Progressive Myotomy in Peroral Endoscopic Esophageal Myotomy in Achalasia: A Randomized Controlled Trial

Sponsor: Cairo University • ClinicalTrials.gov ID: NCT07875686

Registry updated: 2026-10-15

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Description

Peroral endoscopic esophageal myotomy (POEM) has been established as an effective therapy for Achalasia. It is still not known how deep the myotomy should be and if it should include the circular and longitudinal muscles or not. It is hypothesized that a complete full thickness myotomy could lead to higher rates of gastroesophageal reflux disease (GERD). In this study we compare performing a Full-thickness myotomy with a progressive myotomy (proximal half circular only, distal half full-thickness, and assessment the different outcomes including efficacy and the incidence of postprocedural GERD.

Interventions

Full thickness myotomy (Procedure)
Full thickness myotomy
Progressive thickness myotomy (Procedure)
Progressive thickness myotomy

Eligibility criteria

Inclusion Criteria: * Achalasia confirmed by manometry * Type 1 and type 2 Achalasia * Eckhart score \>3 * Fit to undergo anaesthesia Exclusion Criteria: * Type 3 achalasia and other esophageal motility Disorders * Hiatus hernia * Coagulopathy

Conditions

Achalasia Cardia Achalasia

Locations

Cairo University — Cairo, Egypt
Theodore Bilharz Institute — Cairo, Egypt

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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