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RECRUITING Not applicable ClinicalTrials.gov

Low Load Blood Flow Restriction Resistance Training in Colorectal Cancer Related Sarcopenia

Sponsor: Ahmed Adel Ahmed Elsayed Ali Radwan • ClinicalTrials.gov ID: NCT07874035

Registry updated: 2026-10-21
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Description

PURPOSE: To investigate the effects of low-load resistance training combined with blood flow restriction on muscle strength, functional performance, and cancer-related fatigue in colorectal cancer survivors with probable sarcopenia. BACKGROUND: Muscle weakness and cancer-related fatigue are prevalent in colorectal cancer survivors with probable sarcopenia and are associated with adverse outcomes. High-load resistance training is often poorly tolerated in this population. Although low-load resistance training with blood flow restriction shows promise, colorectal cancer-specific randomized evidence remains limited. HYPOTHESES: It is hypothesized that low-load blood flow restriction resistance training will lead to significant improvements in muscle strength and functional performance and a significant reduction in cancer-related fatigue in colorectal cancer survivors with probable sarcopenia. RESEARCH QUESTION: Does low-load blood flow restriction resistance training lead to significant improvements in muscle strength and functional performance and a significant reduction in cancer-related fatigue in colorectal cancer survivors with probable sarcopenia?

Interventions

  • Low load blood flow restriction resistance training (Behavioral)
    Low-load resistance training combined with blood flow restriction using pneumatic cuffs applied to the proximal lower limb at 60% arterial occlusion pressure. Resistance exercise is performed at 30% of one-repetition maximum (1RM), using 30-15-15-15 repetitions with 30-60 seconds of rest between sets. The intervention is supervised twice weekly for 12 weeks.
  • Low load resistance training without Blood Flow Restriction (Behavioral)
    Low-load resistance training without blood flow restriction. Resistance exercise is performed at 30% of one-repetition maximum (1RM), using 30-15-15-15 repetitions with 30-60 seconds of rest between sets. The intervention is supervised twice weekly for 12 weeks.

Eligibility criteria

Inclusion Criteria: 1. Colorectal cancer with probable sarcopenia. 2. Age 40-59 years. 3. Low muscle strength defined by EWGSOP2 criteria using the five-times sit-to-stand test (\>15 seconds without upper limb support). 4. Current chemotherapy/radiotherapy or postoperative status with confirmed medical stability. 5. Medical clearance for supervised exercise. 6. Ability to follow instructions and complete assessments. Exclusion Criteria: 1. Any contraindication to resistance or blood flow restriction training. 2. Uncontrolled cardiovascular disease or hypertension. 3. Recent thromboembolic events. 4. Severe peripheral vascular disease. 5. Uncontrolled treatment-related complications, such as severe anemia or infection. 6. Metastatic bone disease in the lower limbs. 7. Neurological or musculoskeletal disorders limiting safe participation.

Conditions

Colorectal Cancer Survivors

Locations

  • Private Clinics — Cairo, Egypt
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record