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RECRUITING Not applicable ClinicalTrials.gov

Nano-Silver Versus Bioactive Glass for Primary Teeth Exposed to Therapeutic Radiation

Sponsor: Faculty of Dental Medicine for Girls • ClinicalTrials.gov ID: NCT07866482

Registry updated: 2026-10-08
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Description

This study aims to evaluate and compare the remineralizing and antimicrobial effects of nano silver fluoride and bioactive glass gel on primary teeth exposed to therapeutic radiation. The study includes both in vitro and in vivo components. The clinical component will include 30 pediatric patients aged 6-10 years undergoing therapeutic head and neck radiotherapy. Participants will be randomly allocated into two groups to receive either nano silver fluoride or bioactive glass gel. The effects of the interventions will be evaluated using salivary pH and bacterial count measurements. The laboratory component will evaluate changes in irradiated primary tooth enamel, including surface morphology, mineral content, and microhardness.

Interventions

  • Nano Silver Fluoride (Other)
    Nano silver fluoride solution will be topically applied once for 1 minute
  • Bioactive Glass Gel (Other)
    Bioactive glass gel will be topically applied once daily for 1 minute for 7 consecutive days

Eligibility criteria

Inclusion Criteria: * Pediatric patients undergoing therapeutic head and neck radiotherapy. * Age 6 to 10 years. * Presence of at least one sound primary tooth. * The oral cavity lies within the radiotherapy field during treatment. * Written informed consent obtained from a parent or legal guardian. Exclusion Criteria: * Systemic diseases affecting tooth mineralization. * Use of medications known to influence salivary flow or enamel integrity, other than radiotherapy. * Edentulous upper and lower jaws. * Extensive dental caries or severe enamel defects. * Habitual mouth breathing. * Uncooperative patients or lack of parental consent.

Conditions

Radiation Caries

Locations

  • National Cancer Institute, Cairo University — Cairo, Cairo Governorate, Egypt
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record