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RECRUITING Phase 1 / Phase 2 ClinicalTrials.gov

Tributyrin for Progressive Supranuclear Palsy (PSP): Virtual Trial

Sponsor: Prabesh Kanel • ClinicalTrials.gov ID: NCT07863180

Registry updated: 2026-10-07
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Description

This research is studying a supplement called tributyrin in people with Progressive Supranuclear Palsy (PSP) to learn about its safety and tolerability as a potential treatment. The goal of this research study is to see if a similar supplementation regimen and virtual testing is feasible for people with PSP.

Interventions

  • Tributyrin (Drug)
    Post-biotic short chain fatty acid dietary supplement. Participants will take 500mg TID tributyrin supplement for 90 days +/- 7 days.
  • Placebo (Drug)
    Participants will take 500mg TID placebo for 90 days +/- 7 days.

Eligibility criteria

Inclusion Criteria: * Male or Female, age 45 years and over. * Diagnosis of PSP-Richardson syndrome (RS) based on Movement Disorder Society (MDS) Criteria, including 1. Vertical supranuclear gaze palsy. 2. Repeated unprovoked falls OR tendency to fall on the pull test within 3 years. * Access to the internet and webcam for virtual visits. * Presence of a caregiver. Exclusion Criteria: * Recent history of significant, uncontrolled GI disease such as Gastroesophageal reflux disease, colorectal cancer. * Significant metabolic or uncontrolled medical comorbidity. * Regular use of typical anti-cholinergic drugs. * Women of child-bearing potential, or who are pregnant and/or nursing. * Suicidal ideation, as indicated by a response of 2 or 3 on question 9 of the Beck Depression Inventory. * Any other condition or criterion that, in the opinion of the investigators, would preclude safe and meaningful participation in the study.

Conditions

Parkinson Disease Multiple System Atrophy Progressive Supranuclear Palsy(PSP)

Locations

  • Domino's Farms — Ann Arbor, Michigan, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record