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RECRUITING Not applicable ClinicalTrials.gov

Role of Postpartum Furosemide in Recovery of Patients With Severe Preeclampsia

Sponsor: Lady Reading Hospital, Pakistan • ClinicalTrials.gov ID: NCT07861685

Registry updated: 2026-10-06
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Description

This randomized controlled trial will compare oral furosemide with placebo for improving blood pressure control in women with severe preeclampsia after delivery. Participants will receive either 20 mg of furosemide or a placebo tablet once daily for 5 days, in addition to standard postpartum treatment for high blood pressure. Blood pressure, symptoms, adverse events, and the need for additional antihypertensive medication will be monitored for 7 days after delivery. The study will assess whether adding furosemide helps achieve better postpartum blood pressure control compared with placebo.

Interventions

  • Furosemide and Potassium (Drug)
    Furosemide 20 mg tablet administered orally once daily for 5 days after delivery as an add-on to standard postpartum antihypertensive treatment.
  • Placebo (Drug)
    Placebo tablet administered orally once daily for 5 days after delivery, in addition to standard postpartum antihypertensive treatment, including blood pressure monitoring and labetalol when required.

Eligibility criteria

Inclusion Criteria: * Women aged 18 to 45 years * Any parity * Gestational age \>28 weeks based on LMP * Severe preeclampsia as per the study operational definition Exclusion Criteria: History of underlying cardiac disease during pregnancy or postpartum * Pre-existing renal dysfunction or serum creatinine \>1.2 mg/dL on medical record * Significant hypokalemia (K \<3 mEq/L) before enrollment * Known rheumatologic disease or advanced diabetes * History of allergy to furosemide or prior use of diuretics before randomization * History of thyroid disorders or other medical illnesses that may interfere with blood pressure management

Conditions

Severe Preeclampsia

Locations

  • Lady Reading Hospital — Peshawar, Khyber Pakhtunkhwa, Pakistan
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record