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RECRUITING Not applicable ClinicalTrials.gov

Stellate Ganglion Block and Dexmedetomidine for Postoperative Sleep in Women Undergoing Laparoscopic Gynecologic Surgery

Sponsor: Catherin Zhang • ClinicalTrials.gov ID: NCT07860203

Registry updated: 2026-10-06
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Description

Study Objectives This study aims to investigate the effects of preoperative stellate ganglion block and intraoperative intravenous dexmedetomidine on postoperative sleep disturbance in patients undergoing laparoscopic gynecologic surgery, with the goals of reducing pain and postoperative adverse reactions and identifying an effective, safe, economical, and broadly applicable intervention strategy that may facilitate emergence from anesthesia, accelerate postoperative recovery, shorten the length of hospital stay, and reduce hospitalization costs. This trial aims to determine whether preoperative stellate ganglion block (SGB) and intraoperative intravenous dexmedetomidine (DEX) can improve postoperative sleep quality in patients undergoing laparoscopic gynecologic surgery, and whether the combination of these two interventions provides an interaction effect or additional ben

Interventions

  • DEX 0.2 μg/kg/h. (Drug)
    Dexmedetomidine is administered by intravenous infusion after induction of anesthesia without a loading dose, at an infusion rate of 0.2μg·kg-¹·h-¹, and continued until the end of surgery.
  • SGB (Procedure)
    Stellate ganglion block (SGB) is performed 15 min after induction of anesthesia by an anesthesiologist experienced in ultrasound-guided regional anesthesia, who is aware of the patient's group assignment. The patient is placed in the supine position with the neck slightly extended and rotated to the contralateral side. Under sterile conditions, a high-frequency linear-array ultrasound transducer is used to scan the anterior neck transversely at the C6 level, sequentially identifying the common carotid artery, internal jugular vein, thyroid gland, esophagus, C6 transverse process and anterior tubercle, longus colli muscle, and surrounding vascular structures. In the SGB group, an in-plane needle approach is used under real-time ultrasound guidance. After the needle tip reaches the fascial plane anterior to the longus colli muscle and negative aspiration for blood is confirmed, 5 mL of 0.375% ropivacaine is injected slowly. Spread of the local anesthetic along the surface of the longus
  • 0.9% Sodium Chloride (Placebo) (Drug)
    An equal volume of 0.9% sodium chloride solution is administered by intravenous infusion after induction of anesthesia as a placebo for dexmedetomidine and continued until the end of surgery.
  • Sham Stellate Ganglion Block (Procedure)
    Participants are placed in the same position as those receiving the stellate ganglion block, and the ultrasound probe is placed on the neck in an identical manner to simulate the procedure. No needle puncture or drug injection is performed.

Eligibility criteria

Inclusion Criteria: 1. Patients with American Society of Anesthesiologists (ASA) physical status I-III; 2. Age 18-75 years; 3. Scheduled to undergo laparoscopic gynecologic surgery (laparoscopic hysterectomy or laparoscopic surgery for uterine fibroids). Exclusion Criteria: 1. Preoperative sore throat or hoarseness; 2. History of upper respiratory tract infection within the previous 2 weeks; 3. Anticipated difficult tracheal intubation (Mallampati class III or IV, potential facial deformity, mouth opening \<3 finger breadths, etc.); 4. Severe preoperative cardiac, hepatic, renal, or other organ dysfunction; 5. Allergy to the local anesthetic used in the study, infection at the puncture site, or coagulation abnormalities; 6. Cognitive impairment, hearing impairment, language impairment, a history of psychiatric illness, or difficulty communicating or cooperating because of a psychiatric disorder.

Conditions

Uterine Fibroids (Leiomyoma) Adenomyosis of Uterus Endometriosis Endometrial Cancer Cervical Cancer Ovarian Cancer

Locations

  • Huai'an Second People's Hospital — Huai'an, Jiangsu, China
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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