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RECRUITING Not applicable ClinicalTrials.gov

Calcium Gluconate Activated in Anterior Disc Displacement With Reduction of the Temporomandibular Joint

Sponsor: Cairo University • ClinicalTrials.gov ID: NCT07855887

Registry updated: 2026-10-02
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Description

To compare the efficacy of retro discal injection of calcium gluconate-activated PRP versus non-activated PRP in adults with Anterior Disc Displacement with Reduction (ADDWR). Efficacy will be measured by the reduction of symptoms and the restoration of function, specifically targeting the normal Maximum Mouth Opening (MMO) range

Interventions

  • activated platelet-rich plasma (Procedure)
    Intra-articular retrodiscal injection of autologous platelet-rich plasma (PRP) activated with 0.5 milliliters of 10% sterile calcium gluconate per 5 milliliters of prepared PRP, administered as a single anatomical landmark-guided injection into the retrodiscal tissue.
  • non-activated platelet-rich plasma (Procedure)
    Intra-articular retrodiscal injection of autologous non-activated platelet-rich plasma, prepared using identical double-centrifugation technique and administered using identical injection protocol and volume

Eligibility criteria

Inclusion Criteria: * Adults aged 18-65 years. * Clinical and MRI diagnosis of ADDWR per DCTMD criteria. * Baseline VAS pain score 4-10. * Failure of at least 2 conservative treatments (splint therapy, physiotherapy, NSAIDs) for 3 months. * Written informed consent. Exclusion Criteria: * • Systemic inflammatory arthritis (Rheumatoid arthritis, etc.). * Recent TMJ surgery or intra-articular injection within the last 6 months. * Pregnancy or lactation. * Active TMJ infection or malignancy. * Coagulopathy or anticoagulant therapy. * Contraindications to MRI (e.g., pacemaker).

Conditions

Temporomandibular Joint Disorders

Locations

  • Cairo University — Cairo, Egypt
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record