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Clinical and Radiographic Evaluation of UV-Treated Dental Implants With or Without Melatonin in the Upper Posterior Jaw

Sponsor: Mansoura University • ClinicalTrials.gov ID: NCT07853976

Registry updated: 2026-10-02

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Description

The purpose of this study is to evaluate and compare the clinical and radiographic outcomes of using photofunctionalized (UV-treated) dental implants with or without the application of melatonin hormone in the posterior maxilla (upper back jaw). The posterior maxilla is known to have lower bone quality, which can negatively affect the primary and secondary stability of dental implants,. UV photofunctionalization is a method that modifies the titanium surface of the implant, changing it from hydrophobic (water-repelling) to superhydrophilic (water-attracting). This enhancement aims to accelerate protein adsorption and promote bone-building cells (osteoblasts). On the other hand, melatonin acts as an anti-inflammatory and antioxidant agent that stimulates bone formation and reduces bone resorption. A total of 21 dental implants will be placed in patients requiring tooth replacement in the posterior maxilla. The implants will be divided into three main approaches: one using UV-treated implants alone, and the other combining UV-treated implants with melatonin. and one using conventional implant Patients will be followed up clinically and radiographically to assess implant stability, bone healing, and overall implant success over time.

Interventions

UV-Photofunctionalized Dental Implant (Device)
Commercial titanium dental implants subjected to ultraviolet (UV) light irradiation immediately prior to surgical placement to convert the surface property from hydrophobic to superhydrophilic.
Conventional Dental Implant (Device)
Standard commercial titanium dental implants placed using traditional surgical protocols without any UV surface photofunctionalization or melatonin application.

Eligibility criteria

Inclusion Criteria: * Patients aged between 18 and 60 years old. * Patients seeking replacement of missed single or multiple teeth in the posterior maxilla. * Sufficient bone volume (height and width) to accommodate dental implant placement without major bone grafting. * Good oral hygiene and motivated patients. * Systemically healthy patients with no contraindications for minor oral surgery. Exclusion Criteria: * Patients with uncontrolled systemic diseases * Patients who received radiation therapy in the head and neck region within the last 5 years. * Heavy smokers (more than 10 cigarettes per day). * Patients with active periodontal disease or poor oral hygiene. * Pregnant or lactating females. * Parafunctional habits such as severe bruxism or clenching.

Conditions

Jaw, Edentulous, Partially Bone Resorption Dental Implant Failure

Locations

Faculty of Dentistry, Mansoura University — Al Mansurah, Dakahlia Governorate, Egypt

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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