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Sex Hormones and Aging

Sponsor: University of Michigan • ClinicalTrials.gov ID: NCT07848438

Registry updated: 2026-09-30

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Description

This study investigates the influence of sex hormones and exercise on age-related neuromuscular decline in females. Specifically, the research aims to evaluate how hormonal variations impact both age-associated neuromuscular decline and the subsequent adaptations to exercise and resistance training. Age-related declines in neuromuscular function are especially pronounced in females, potentially due to the sharp drop in estradiol after menopause. This project will compare postmenopausal females who have not taken hormonal therapy (HT) to age-matched females taking HT.

Interventions

HRT: High-Resistance Strength Training (Other)
Each participant will attend 2 sessions per week for 8 weeks. A training session will start with a 10-minute full body dynamic warm-up (e.g., bodyweight movements and mobility exercises). The participant will then perform bilateral lower body high-resistance strength training exercises (leg extension and leg press) for 4 sets of 8-10 repetitions.
Control: High-Resistance Strength Training (Other)
Each participant will attend 2 sessions per week for 8 weeks. A training session will start with a 10-minute full body dynamic warm-up (e.g., bodyweight movements and mobility exercises). The participant will then perform bilateral lower body high-resistance strength training exercises (leg extension and leg press) for 4 sets of 8-10 repetitions.

Eligibility criteria

Inclusion Criteria: Exclusion Criteria: * Females who are pregnant or likely to be pregnant. Female subjects of childbearing age will be asked of the possibility of pregnancy and will be excluded from the study if they are pregnant or become pregnant during the study. * Females who are not currently taking HT but have taken HT in the past 5 years. * Severe obesity (body mass index, BMI, \> 45 kg/m2): this will be calculated from measured height and weight * Untreated hypothyroidism * Uncontrolled blood pressure (\>160/100 mmHg at rest) * Epilepsy or increased risk of seizures * Metal implants in the body, excluding the mouth * Head injury in the past 6 months * People who are taking any of the following medications: Medications that affect cortical excitability, Nonsteroidal anti-inflammatory drug (NSAID) use in the past 24 hours or chronic use of NSAIDs, Beta blockers or any other heart rate stabilizing medications, Any neurological, cardiovascular or musculoskeletal disease that precludes exercise testing

Conditions

Menopause Menopausal Hormone Therapy Aging

Locations

University of Michigan — Ann Arbor, Michigan, United States

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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