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RECRUITING Phase 3 ClinicalTrials.gov

A Study to Learn About Switching to a Monthly Study Medicine Called Berobenatide (PF-08653944) to Help Keep Weight Off in People With Overweight or Obesity

Sponsor: Pfizer • ClinicalTrials.gov ID: NCT07845500

Registry updated: 2026-10-15
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Description

The purpose of this study is to learn about the safety and effectiveness of berobenatide in adults with overweight or obesity who have already lost weight while taking semaglutide or tirzepatide. The study does not include people with diabetes. Participants will be in the study for about 11 months.

Interventions

  • Semaglutide (Drug)
    Participants will receive Semaglutide administered subcutaneously.
  • Berobenatide (Drug)
    Participants will receive berobenatide solution for injection as subcutaneous injection.
  • Tirzepatide (Drug)
    Participants will receive Tirzepatide administered subcutaneously.

Eligibility criteria

Inclusion Criteria: * Aged ≥18 years. * Currently taking semaglutide or tirzepatide for obesity management. Exclusion Criteria: * Diagnosis of any form of diabetes. * History of acute or chronic pancreatitis. * Personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN-2).

Conditions

Obesity Overweight and/or Obesity Overweight Treatment Of Obesity

Locations

  • University of Alabama at Birmingham — Birmingham, Alabama, United States
  • Velocity Clinical Research - Los Angeles — Los Angeles, California, United States
  • Southern California Clinical Research — Santa Ana, California, United States
  • Diablo Clinical Research, LLC dba Flourish Research — Walnut Creek, California, United States
  • Jacksonville Center for Clinical Research — Jacksonville, Florida, United States
  • Suncoast Clinical Research — New Port Richey, Florida, United States
  • Oviedo Medical Research — Oviedo, Florida, United States
  • Monroe Biomedical Research — Louisville, Kentucky, United States
  • Aa Mrc Llc — Flint, Michigan, United States
  • SKY Integrative Medical Center/SKYCRNG — Ridgeland, Mississippi, United States
  • Clinical Research Professionals — Chesterfield, Missouri, United States
  • Mercury Street Medical Group, PLLC — Butte, Montana, United States
  • Monroe Biomedical Research — Monroe, North Carolina, United States
  • Accellacare - Wilmington — Wilmington, North Carolina, United States
  • Velocity Clinical Research, Mt. Auburn — Cincinnati, Ohio, United States
  • Tribe Clinical Research, LLC — Greenville, South Carolina, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record