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RECRUITING Not applicable ClinicalTrials.gov

Histological and Histomorphometric Assessment With Inflammatory Profile Analysis of Bone Tissue After Horizontal Ridge Augmentation Using Customized Porous Zirconia Shell

Sponsor: Mohammed Mahmoud Abed • ClinicalTrials.gov ID: NCT07841158

Registry updated: 2026-09-30
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Description

The goal of this clinical study is to learn whether a custom-made porous zirconia shell can support good-quality new bone when widening the lower back jaw before dental implant placement. The study includes adults whose jawbone in this area is too narrow for implants (Seibert Class I defects). The main question it aims to answer is: What is the quality of the new bone formed under a porous zirconia shell, and how much inflammation does the tissue show? Participants will: * Receive gum treatment and a CBCT scan before surgery * Have bone augmentation surgery, in which a digitally designed porous zirconia shell is fixed over a mixture of their own bone and xenograft * Return after 2 weeks for suture removal and a check of the wound * Return after 6 months for a CBCT scan, removal of the shell, collection of a small bone sample (biopsy), and dental implant placement

Interventions

  • Customized porous zirconia shell (Device)
    A CAD/CAM-milled zirconia shell with 1.5 mm pores, designed from each patient's CBCT scan and fixed with 3-4 buccal screws over a 1:1 mix of autogenous bone chips and xenograft. It replaces the autogenous cortical plates used in the Khoury technique and is removed after 6 months.

Eligibility criteria

Inclusion Criteria: * Age more than 21 years old * Horizontal bone loss in the lower posterior area (Seibert Class I) * Enough inter-arch space for placement of implant-supported prosthesis * Motivated patient to have the treatment * Good oral hygiene Exclusion Criteria: * Patients with systemic conditions that could interfere with the healing process * Pregnant females * Smokers * Poor oral hygiene

Conditions

Alveolar Bone Loss Alveolar Ridge Deficiency

Locations

  • October University for Modern Sciences and Arts (MSA), Faculty of Dentistry — Giza, Giza Governorate, Egypt
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record