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Aerobic Exercise and Connective Tissue Massage in Painful Bladder Syndrome

Sponsor: Hacettepe University • ClinicalTrials.gov ID: NCT07839689

Registry updated: 2026-09-24

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Description

The goal of this clinical trial is to learn if aerobic exercise training and connective tissue massage, in addition to patient education, can help treat women with bladder pain syndrome. The main questions it aims to answer are: Does aerobic exercise training and connective tissue massage reduce bladder-related pain severity? Does this intervention improve urinary symptoms, pain sensitivity, central sensitization-related symptoms, psychological symptoms, and quality of life? Researchers will compare patient education plus aerobic exercise training and connective tissue massage with patient education alone to see if the combined physiotherapy program is more effective. Participants will: Receive patient education about bladder pain syndrome Be randomly assigned to one of two groups Receive either patient education alone or patient education together with aerobic exercise training and connective tissue massage for 8 weeks Complete assessments at the beginning of the study and after 8 weeks

Interventions

Patient Education (Behavioral)
Participants will receive patient education about bladder pain syndrome, symptom management, lifestyle recommendations, and strategies to support self-management. This intervention will be provided to both study groups.
Aerobic Exercise Training (Behavioral)
Participants in the intervention group will receive an 8-week aerobic exercise training program in addition to patient education.
Connective Tissue Massage (Other)
Participants in the intervention group will receive connective tissue massage in addition to patient education and aerobic exercise training. The intervention will be delivered by a physiotherapist according to the study protocol as part of the 8-week multimodal physiotherapy program.

Eligibility criteria

Inclusion Criteria: * Female individuals aged 18 years or older * Diagnosis of bladder pain syndrome * Bladder-related pain, discomfort, and/or burning symptoms lasting for at least 6 months * Bladder-related symptom severity, including pain, discomfort, and/or burning, of at least 3 cm on the Visual Analog Scale during the last week * Receiving stable medical treatment * Being medically suitable for moderate-intensity aerobic exercise according to the Physical Activity Readiness Questionnaire * Volunteering to participate in the study and signing the informed consent form * For individuals aged 65 years or older, a Mini-Mental State Examination score of 24 or higher Exclusion Criteria: * Presence of acute urinary tract or urogynecological infection * Pregnancy and/or breastfeeding * Diagnosis of pelvic, urological, and/or gynecological malignancy or history of pelvic radiotherapy * Pelvic or abdominal surgery within the last 6 months * Presence of congenital urinary system anomalies * History of neurological disease or diagnosis of neurogenic bladder * Open wound or active skin infection in the area where manual therapy will be applied

Conditions

Bladder Pain Syndrome Painful Bladder Syndrome Painful Bladder Syndrome (PBS) Interstitial Cystitis and Bladder Pain Syndrome Interstitial Cystitis/Painful Bladder Syndrome

Locations

Hacettepe University Faculty of Physical Therapy and Rehabilitation — Ankara, Ankara, Turkey (Türkiye)

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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