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Integrated Motor-Cognitive Training in Parkinson's Disease: A Feasibility Study

Sponsor: University Hospital of Ferrara • ClinicalTrials.gov ID: NCT07833748

Registry updated: 2026-09-22

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Description

Parkinson's disease is a progressive neurodegenerative condition characterized by both motor symptoms (such as bradykinesia, rigidity, tremor, and postural instability) and non-motor symptoms, including cognitive impairments (affecting working memory, executive functions, and attention). Combined interventions that target both domains simultaneously or consecutively have shown potential to produce superior benefits compared to isolated motor or cognitive training. The purpose of this study is to evaluate the feasibility, adherence, and preliminary clinical results of efficacy of an integrated and combined motor-cognitive rehabilitation training in patients diagnosed with Parkinson's disease. This feasibility study will enroll 12 participants with Parkinson's disease. All participants will undergo a comprehensive 10-session integrated rehabilitation program combining digital cognitive individual stimulation and group functional motor training. The primary focus is to assess acceptability, safety, and adherence to this combined approach, while secondary outcomes will observe changes in relevant cognitive and motor clinical variables.

Interventions

Combined group motor training and individual digital cognitive stimulation (Behavioral)
Participants complete a 10-session motor-cognitive training program (3 times per week). Interventions occur on the same day in groups of 3, supervised by a neuropsychologist and physiotherapist. * Cognitive Session (30 min): Training delivered individually and tailored to baseline, individual-specific deficits using the NeuronUP application. Each session includes 5 gamified exercise types (4 minutes each) with adaptive difficulty and optional 2-minute breaks. * Motor Session (1 h): Group circuit of 6 stations (7 minutes for station, 2-min breaks): Stations 1-2: Cardiovascular (stepping, sit-to-stand); 3: Dynamic balance with external constraints (stepping over obstacles); 4: Dynamic balance with internal constraints (walking around obstacles); 5: Static balance exercises; 6: Functional movement transfers (Floor-to-standing)

Eligibility criteria

Inclusion Criteria: * Diagnosis of Parkinson's disease * Presence of motor symptoms attributable to Parkinson's disease * Availability to participate in both treatments (cognitive and motor) * Severity of symptoms compatible with participation in group physical therapy * Absence of other medical conditions that could interfere with treatment delivery * Montreal Cognitive Assessment (MoCA) score \>= 18 * Consent to participate in group-based motor training * Absence of falls in the 3 months prior to baseline evaluation Exclusion Criteria: * Concomitant major neurological or psychiatric disorders * Severe cardio-pulmonary, renal, or hepatic diseases * Changes in baseline pharmacological therapy within 3 months prior to enrollment

Conditions

PARKINSON DISEASE (Disorder)

Locations

Ferrara University Hospital — Ferrara, FE, Italy

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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