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RECRUITING Not applicable ClinicalTrials.gov

CAIX-targeted PET/CT in Solid Tumors

Sponsor: Zhongnan Hospital • ClinicalTrials.gov ID: NCT07833085

Registry updated: 2026-10-13
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Description

Tumor hypoxic microenvironment plays an important role in the initiation and progression of solid tumors, as well as tumor invasion, metastasis, and treatment resistance. Carbonic anhydrase IX (CAIX), as a crucial downstream molecule regulated by hypoxia-inducible factor-1 (HIF-1), is highly expressed in various solid tumors and is closely associated with tumor invasiveness, treatment response, and prognosis; thus, it represents an ideal target for tumor diagnosis and therapy. This study aims to explore the diagnostic value of CAIX-targeted PET/CT imaging in various solid tumors, as well as the correlation between tumor uptake and tissue CAIX expression.

Interventions

  • 68Ga-CAIX (Diagnostic test)
    The subjects receive a PET/CT scan 30-60 minutes after intravenous administration of 68Ga-CAIX

Eligibility criteria

Inclusion Criteria: * Participants with suspected malignant solid tumors or patients with newly diagnosed or recurrent/metastatic malignant solid tumors confirmed by histopathology; * Age of 18 years and above, both male and female are eligible; * The ECOG PS score for physical condition in the Eastern Cancer Collaboration Group is 0-1 points; * Research participants voluntarily sign informed consent forms or have their parents/children/legal guardians sign informed consent forms, and are able to complete the trial according to the requirements of the research protocol. Exclusion Criteria: * Participants with severe liver and kidney dysfunction and cardiac dysfunction; * Participants with severe obesity, claustrophobia, or other reasons who are unable to undergo PET scans; * Pregnant or lactating women; * Other situations that researchers believe should be excluded and documented.

Conditions

Malignant Solid Tumors Clear Cell Renal Cell Carcinoma Lung Cancer (NSCLC) Breast Cancer

Locations

  • Zhongnan hospital of Wuhan University — Wuhan, Hubei, China
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record