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Analysis of Cerebrospinal Fluid Dynamics in Normal Pressure Hydrocephalus

Sponsor: Chungnam National University Hospital • ClinicalTrials.gov ID: NCT07831044

Registry updated: 2026-09-21

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Description

This study aims to evaluate whether phase-contrast magnetic resonance imaging (MRI)-based cerebrospinal fluid (CSF) flow dynamics can improve the diagnosis and prognostic assessment of normal pressure hydrocephalus (NPH). In addition, the study investigates how changes in CSF flow parameters before and after CSF diversion procedures are associated with clinical improvement.

Interventions

Cerebrospinal fluid drainge (Procedure)
Cerebrospinal fluid drainge

Eligibility criteria

Inclusion Criteria: * Patients presenting with clinical symptoms consistent with normal pressure hydrocephalus (presence of gait disturbance accompanied by at least one of the following: cognitive impairment or urinary dysfunction) * Evans' ratio ≥ 0.3 on brain MRI Exclusion Criteria: * Patients who cannot undergo CSF drainage due to structural abnormalities of the lumbar spine * Contraindications to lumbar puncture and CSF drainage (e.g., local infection at the puncture site, suspected elevated intracranial pressure, platelet count \< 40,000/µL, or coagulopathy) * Coexisting neurological disorders that can also cause gait disturbance, such as Parkinson's disease, atypical parkinsonian syndromes, or vascular parkinsonism * Contraindications to MRI (e.g., presence of cardiac pacemakers, implantable defibrillators, or other non-MRI-compatible implantable medical devices)

Conditions

Normal Pressure Hydrocephalus

Locations

Chungnam National University Hospital — Daejeon, Jung-gu, South Korea

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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