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RECRUITING Phase 2 ClinicalTrials.gov

Beta-amyloid PET/CT to Measure Potential Therapeutic Response in AL-CA

Sponsor: Peking Union Medical College Hospital • ClinicalTrials.gov ID: NCT07829705

Registry updated: 2026-09-21
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Description

This was a single center, prospective cohort study that is evaluating the ability of beta-amyloid dynamic PET/CT to detect potential therapeutic changes in subjects under treatment for AL-CA after one year had elapsed since their baseline beta-amyloid PET/CT. Demographic, clinical and PET imaging data were collected to characterize potential changes since their baseline scans.

Interventions

  • 11C-PIB (Drug)
    A dosage range between 5.0-20.0 mCi of 11C-PIB will be injected by a PET-certified medical professional followed by 5ml 0.9% sodium chloride (normal saline) flush.
  • 18F-Florbetapir (Drug)
    A dosage range between 6.0-12.0 mCi of 18F-Florbetapir will be injected by a PET-certified medical professional followed by 5ml 0.9% sodium chloride (normal saline) flush.

Eligibility criteria

Inclusion Criteria: 1. Age ≥ 18 y； 2. were proven newly diagnosed AL-CA by standard criteria; 3. subsequently received first-line therapies including anti-plasma cell therapy or targeted therapy; 4. must have given written informed consent (signed and dated) and any authorizations required by local law and be able to comply with all study requirements. Exclusion Criteria: 1. received therapy with an approved treatment (e.g., Bortezomib, Daratumumab) prior to enrollment; 2. pregnancy or breastfeeding; 3. severe claustrophobia; 4. any condition deemed by the investigator to interfere with study results or increase participant risk.

Conditions

Light Chain Cardiac Amyloidosis

Locations

  • Peking Union Medical College Hospital — Beijing, China
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record