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Short-term Spinal Stimulation Effects in Cerebral Palsy

Sponsor: University of Washington • ClinicalTrials.gov ID: NCT07826494

Registry updated: 2026-09-17

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Description

This research study will examine the acute effects of non-invasive spinal stimulation on spasticity and walking in individuals with cerebral palsy. The hypothesis is that walking with spinal stimulation will lead to greater reductions in spasticity than walking without spinal stimulation. Additionally, it is hypothesized that the average step length and Gait Deviation Index will be higher while walking with spinal stimulation compared to walking without spinal stimulation.

Interventions

Spinal Stimulation (Device)
A stimulator will be used non-invasively stimulate the spine at the neck and/or lower back (cervical and/or lumbar).
Treadmill Walking (Other)
Participant will walk on a treadmill.

Eligibility criteria

Inclusion Criteria: Individuals who: * have a diagnosis of spastic cerebral palsy or high likelihood of CP diagnosis * are 4-65 years of age * have spasticity in lower-extremity muscles * are at a functional Gross Motor Function Classification System (GMFCS) Level I-III * can walk for at least 10 minutes with/without support * can understand and follow simple directions * have a stable medical condition, as reported by the caregiver/parent Exclusion Criteria: Individuals who: * who have had lower-extremity surgery or injury in the prior 12 months * have had botulinum toxin injections in the prior 3 months * have had selective dorsal rhizotomy (SDR) in the past * have uncontrolled seizures * have significant cardiovascular or musculoskeletal disease that would prevent full participation * are dependent on ventilation support * have implanted stimulator (e.g. epidural stimulator, vagus nerve stimulator, pacemaker, cochlear implant, etc) or drug delivery device (e.g. baclofen pump) * have established osteoporosis and taking medication for osteoporosis treatment. * have rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus, etc.) * have active cancer * have received stem cell injections into the spinal cord

Conditions

Cerebral Palsy

Locations

University of Washington — Seattle, Washington, United States

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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