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RECRUITING Not applicable ClinicalTrials.gov

Inter-Limb Transfer in Acute Stroke

Sponsor: University Hospital of Mont-Godinne • ClinicalTrials.gov ID: NCT07822633

Registry updated: 2026-09-16
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Description

This study aims to investigate whether the improvements achieved through motor skill learning (MSkL) with the ipsilesional upper limb (UL) are transferred to the contralesional UL during the (sub)acute stroke phase, and to identify the neural substrates underlying this inter-limb transfer. To achieve this, healthy individuals, acute and chronic stroke patients will perform proximal and distal MSkL tasks using serious games implemented on robotic devices. This will be complemented by behavioural assessments and multimodal MRI.

Interventions

  • REAplan® (Device)
    motor skill learning with the REAplan® rehabilitation robot, to be performed with ipsilesional arm
  • Dextrain Manipulandum® (Device)
    motor skill learning with the Dextrain Manipulandum® dexterity tool to be performed with ipsilesional hand
  • REAplan® (Device)
    proximal motor control and motor skill assessement with the REAplan® rehabilitation robot, to be performed by each arm
  • Dextrain Manipulandum® (Device)
    distal motor skill assessment with the Dextrain Manipulandum® dexterity tool to be performed by each hand

Eligibility criteria

ACUTE STROKE PATIENTS: Inclusion Criteria: * First acute ischemic or hemorrhagic stroke * Between the 2nd and 21st day post-stroke * Age: 40-90 years * Ability to complete the 3 consecutive sessions Exclusion Criteria: * Stroke with multiple brain lesions * Addiction (e.g., alcohol or drugs) * Pregnancy * Major cognitive impairment (e.g., depression, aphasia, dementia) * Inability to perform or understand the required tasks * Uncontrolled health conditions * " classical " contre-indication to MRI (non-MR-compatible pacemaker, pregnancy, non-MR-compatible implanted devices, claustrophobia, etc ...) HEALTHY INDIVIDUALS: Inclusion Criteria: * 40-90 years * availability to complete three consecutive sessions. Exclusion Criteria: * "classical" contre-indication to MRI (non-MR-compatible pacemaker, pregnancy, non-MR-compatible implanted devices, claustrophobia, etc ...) * medical history with a previous stroke/relevant neurological deficit or disease * drug/alcohol abuse * psychiatric condition/dementia * having already used the robotic devices CHRONIC STROKE PATIENTS: Inclusion Criteria: * single stroke confirmed by brain imaging * time since stroke onset \>6 months * age between 40-90 years * availability to complete three consecutive sessions. Exclusion Criteria: * Stroke with multiple brain lesions * Addiction (e.g., alcohol or drugs) * Pregnancy * Major cognitive impairment (e.g., depression, aphasia, dementia) * Inability to perform or understand the required tasks * Uncontrolled health conditions * having already used the robotic devices

Conditions

Stroke, Acute Stroke (Subacute) Healthy Individuals (Controls) Chronic Stroke Patients

Locations

  • CHU UCL Namur — Yvoir, Namur, Belgium
  • Cliniques universitaires Saint-Luc — Brussels, Belgium
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record