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Different Approaches for Alveolar Ridge Preservation

Sponsor: Danae A. Apatzidou • ClinicalTrials.gov ID: NCT07818447

Registry updated: 2026-09-25

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Description

Following tooth extraction, physiologic remodeling of the alveolar ridge results in significant horizontal and vertical bone resorption, often accompanied by soft tissue collapse. These dimensional changes may complicate future implant placement and compromise esthetic and functional outcomes. Alveolar ridge preservation techniques have been introduced to limit post-extraction tissue loss by supporting bone regeneration and stabilizing the soft tissues. A previously conducted study has shown optimal wound healing of a guided bone regeneration technique by employing a non-submerged barrier membrane versus a socket seal technique employing a free gingival graft versus unassisted healing. This prospective randomized controlled clinical trial aims to evaluate the effectiveness of alveolar ridge preservation using the combination of an allograft with either a platelet-rich fibrin (PRF) membrane, versus combination of an allograft with a barrier membrane versus spontaneous healing after tooth extraction. A total of fifty-one subjects will be randomly allocated into three treatment groups. Clinical and radiographic (periapical radiograph, CBCT) outcomes will be assessed at baseline, and 3 months post-extraction.

Interventions

Bone Allograft + Autologous Platelet-Rich Fibrin (PRF) Membrane (Procedure)
Preparation of the PRF membrane. Placement of particulate bone allograft (ALO580-CTBA) and enrichment with injectable PRF (i-PRF). Placement of the PRF membrane over the socket entrance in a manner similar to the GBR membrane.
Control group (Other)
Atraumatic tooth extraction and spontaneous healing.
Bone Allograft + Resorbable Guided Bone Regeneration Membrane (Procedure)
Atraumatic tooth extraction, placement of allograft (ALO580-CTBA) and barrier PLGA membrane Septodont RTR+ Membrane®)

Eligibility criteria

Inclusion Criteria: * Age ≥18 years. * Requirement for extraction of a single tooth affected by periodontal disease. * Presence of at least one adjacent tooth. * Loss of the buccal alveolar bone wall involving up to 50% of the socket wall. * Good general systemic health (American Society of Anesthesiologists ASA Physical Status I or II). * Satisfactory oral hygiene. * Ability to understand the study procedures and provide written informed consent. Exclusion Criteria: * Systemic diseases or medications known to affect bone or soft tissue healing (e.g., uncontrolled diabetes mellitus, osteoporosis treated with bisphosphonates, or immunosuppressive therapy). * Heavy smoking (\>10 cigarettes/day). * Pregnancy or breastfeeding. * Presence of an acute infection or abscess at the extraction site. * History of radiotherapy to the head and neck region. * Inability or unwillingness to comply with the study protocol or attend scheduled follow-up visits.

Conditions

Alveolar Ridge Resorption

Locations

Aristotle University of Thessaloniki, School of Dentistry, Faculty of Health Sciences, Postgraduate Periodontology Department — Thessaloniki, Thessaloniki, Greece

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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