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CREO - Microwave Ablation Feasibility Study

Sponsor: Banner Health • ClinicalTrials.gov ID: NCT07817147

Registry updated: 2026-09-14

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Description

The goal of this study is to assess the overall success of energy delivery during treatment using the ultrasound guided microwave ablation device in patients with locally advanced, unresectable, or metastatic cancer. Secondly, this study aims to explore the procedural/clinical safety of treatment with the device and the antitumor effect following treatment with the device.

Interventions

EUS-Guided MWA Device (Device)
The rationale of this study is to generate preliminary data on the functionality and safety of Creo's MicroBlate™ Fine device when used under EUS guidance. The results generated from this study will inform any decisions regarding subsequent pivotal trials and may support the integration of this approach into clinical practice for anatomically challenging tumors.

Eligibility criteria

Inclusion Criteria: * Male or female ≥18 years of age * Willing and able to provide written informed consent * Histologically confirmed locally advanced, unresectable or metastatic cancer (Stage III or IV) * At least 1 tumor that is indicated for MWA, and the location of target tumor must be accessible via EUS through the gastric wall (eg, pancreas, liver, etc). * The tumor(s) must be ≥1 cm in diameter Exclusion Criteria: * Participant is a candidate for upfront resection of pancreatic cancer * Participation in another clinical trial that involves local ablation or any other local therapy that could affect the target organ or lesions treated in this study * Any condition that, in the opinion of the investigator, may increase the risk to the participant's safety or well-being

Conditions

Pancreatic Cancer Liver Cancer (Locally Advanced or Metastatic) Pancreatic Cancer Non-resectable Pancreatic Cancer Stage III Pancreatic Cancer Stage IV Liver Cancer Stage IV Liver Cancer Stage IIIa Liver Cancer Stage IIIb Liver Cancer Stage IIIc

Locations

Banner MD Anderson Cancer Center and Gateway Hospital — Gilbert, Arizona, United States
Cedars Sinai — Los Angeles, California, United States
Rush University Medical Center — Chicago, Illinois, United States
Mayo Clinic Rochester — Rochester, Minnesota, United States
University of Tennessee Medical — Knoxville, Tennessee, United States
Memorial Hermann-Texas Medical Center — Houston, Texas, United States
West Virginia University Medicine — Morgantown, West Virginia, United States

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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