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The Effects of Low Intensity Endurance Exercise on Improving Mitochondrial Function, Cell Bioelectrical Impedance Phase Angle, Fatigue and Quality of Life in Lung Cancer Patients With Cancer-related Fatigue

Sponsor: Taipei Medical University • ClinicalTrials.gov ID: NCT07806682

Registry updated: 2026-09-08

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Description

To conduct a randomized controlled trial (RCT) targeting lung cancer patients with cancer-related fatigue to achieve the following objectives: Objective 1: To investigate whether a low-intensity endurance exercise intervention can effectively improve mitochondrial DNA content, mitochondrial function, mitochondrial oxidative phosphorylation complex enzyme concentrations, cellular bioelectrical impedance phase angle, cancer-related fatigue, and quality of life in lung cancer patients with cancer-related fatigue. Objective 2: To explore whether the low-intensity endurance exercise intervention improves cancer-related fatigue and quality of life in lung cancer patients through direct or indirect effects by modulating mitochondrial DNA content, mitochondrial function, mitochondrial oxidative phosphorylation complex enzyme concentrations, and cellular bioelectrical impedance phase angle.

Interventions

Low-Intensity Endurance Continuous Exercise (Behavioral)
Participants perform continuous low-intensity endurance exercise for 30 minutes per day, 5 days per week, for 12 weeks at 75%-80% peak heart rate and RPE 11-12.
Low-Intensity Endurance Interval Exercise (Behavioral)
Participants perform alternating low-intensity endurance training consisting of 3-minute Level 2 exercise and 3-minute Level 1 exercise for 30 minutes per day, 5 days per week, for 12 weeks.

Eligibility criteria

Inclusion Criteria: 1. Patients who are diagnosed with lung cancer by a physician ; 2. Patients aged 20-70 years; 3. Patients who are determined by a physician, after assessment of their physical condition, to be suitable for exercise; 4. Patients who have graduated from elementary school or above. Exclusion Criteria: 1. Patients who are unable to communicate in Mandarin, Taiwanese, or Hakka; 2. Patients who are determined by a physician to be physically unsuitable for performing any exercise.

Conditions

Lung Cancer (Diagnosis)

Locations

Taipei Medical University — Taipei, Taiwan

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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