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RECRUITING Not applicable ClinicalTrials.gov

Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection

Sponsor: University of Chicago • ClinicalTrials.gov ID: NCT07804446

Registry updated: 2026-09-04
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Description

The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will: 1. Be randomly divided into getting their steroid injection on the inside or outside of their knee. 2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.

Interventions

  • Anteromedial Injection (Procedure)
    If randomized to this intervention, patients will receive a corticosteroid injection in the anteromedial side of their knee.
  • Anterolateral Injection (Procedure)
    If randomized to this intervention, patients will receive a corticosteroid injection on the anterolateral side of their knee.

Eligibility criteria

Inclusion Criteria: * Age ≥ 40 * Clinical diagnosis of knee OA with predominant medial compartment symptoms * Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent) * Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee * Able to provide informed consent * Able to complete phone, email, or MyChart follow-ups in English Exclusion Criteria: * Predominant lateral compartment OA or patellofemoral-only OA * Inflammatory arthritis (RA, gout flare, etc.) * Suspected or confirmed joint infection or overlying cellulitis * Prior knee arthroplasty on the index knee * Planned surgery for index knee within 12-week follow-up * Inability to complete follow-up assessments * Other clinician-determined contraindication to CSI

Conditions

Osteoarthitis Osteoarthritic Knee Pain Osteoarthritis (OA) Osteoarthritis (OA) of the Knee Osteoarthritis in the Knee

Locations

  • Bolingbrook Clinic — Bolingbrook, Illinois, United States
  • Hyde Park Clinic — Chicago, Illinois, United States
  • La Grange Clinic — La Grange, Illinois, United States
  • Orland Park Clinic — Orland Park, Illinois, United States
  • Woodridge Clinic — Woodridge, Illinois, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record