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Bioimpedance Spectroscopy (BIS): Fluid Changes in Hemodialysis Patients

Sponsor: Per Ivarsen • ClinicalTrials.gov ID: NCT07803029

Registry updated: 2026-09-03

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Description

In connection with dialysis treatment, fluid and salt balance changes. Some kidney disease patients experience fluid accumulation in the body and need to have excess fluid removed via the dialysis machine. Others have too little fluid in their bodies and experience general symptoms. The amount of fluid that needs to be removed is an individual assessment and can be difficult to determine. Today, fluid removal is determined based on signs such as water in the lungs, swollen legs, and blood pressure. By using a so-called bioimpedance spectroscopy (BIS) device, it os possible measure how much fluid is in the body. However, the calculations that BIS devices use are developed for healthy individuals and do not work optimally during dialysis. Therefore, the investigators will use the actual measurements and compare them with fluid extraction and weight changes to examine their relationship. Hemodialysis patients with ultrafiltration on 3 consecutive dialysis days in order to investigate whether there is a difference in measurements after the long dialysis break and whether the measurements are the same when you are being drawn to your dry weight are included. Other patients without fluid removed during dialysis will be investigated once. I the study the absolute blood volume is also measured, that is, how much fluid is in the bloodstream. This is also an expression of the body's total fluid volume. By combining the various measurements, the study will gain increased knowledge about your hydration status. If the measurement methods have sufficient precision, the use of BIS and measurement of total blood volume may contribute to a more accurate determination of your dry weight.

Interventions

Bioimpedance analysis (Device)
Comparing the perfomance of original data from 3 different bioimpedance apparatur and test there precision and accurary compared to ultrafiltration. And whether the performance of measuring absolut blood volume is better

Eligibility criteria

Inclusion Criteria: Hemodialysis for more than 3 month Hemodynamic stabile during a dialysis session \- Exclusion Criteria: 1. Amputated limbs. 2. Pregnant. 3. Extremity palsy and paralysis. 4. Implanted electronic device (e.g., pacemaker or ICD). 5. Regular use of dialysate sodium proliferation. 6. Hip, knee and shoulder prosthesis. 7. Dialysis fistula in both arms. 8. Inability to give informed consent. 9. History of discontinuation of dialysis treatment prematurely.

Conditions

Hemodialysis

Locations

Aarhus University Hospital — Aarhus, Central Denmark, Denmark

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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