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RECRUITING Not applicable ClinicalTrials.gov

TSBL-Based Versus BMI-Based Biliopancreatic Limb Length in One-Anastomosis Gastric Bypass

Sponsor: National Scientific Center of Surgery named after A.N.Syzganov • ClinicalTrials.gov ID: NCT07796503

Registry updated: 2026-09-01
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Description

This study compares two surgical techniques used during one-anastomosis gastric bypass (OAGB) surgery for patients with severe obesity. During this operation, surgeons create a bypass of part of the small intestine, and the length of this bypassed segment (called the biliopancreatic limb) affects both weight loss and the risk of nutritional side effects. In this trial, one group of patients has the limb length calculated individually based on the measured total length of their small intestine (TSBL-based method), while the other group receives a limb length based on standard body mass index (BMI) categories (BMI-based method). The study compares weight loss outcomes, improvement of obesity-related health problems, and complication rates between the two approaches over 12 months after surgery. The trial is being conducted at a single center in Almaty, Kazakhstan, and plans to enroll 100 patients total; this record reflects an interim analysis based on the first 75 patients enrolled.

Interventions

  • TSBL-based biliopancreatic limb length determination (Procedure)
    Biliopancreatic limb length individualized intraoperatively based on measured total small bowel length (TSBL), calculated as BPL = 0.35 × TSBL, prior to laparoscopic one-anastomosis gastric bypass.
  • BMI-based biliopancreatic limb length determination (Procedure)
    Biliopancreatic limb length determined using standard fixed lengths based on preoperative BMI category (150 cm, 180 cm, or 200 cm), prior to laparoscopic one-anastomosis gastric bypass.

Eligibility criteria

Inclusion Criteria: * Age between 18 and 65 years * BMI ≥35 kg/m² in non-Asian populations or ≥32.5 kg/m² in Asian populations * Presence or absence of metabolic comorbidities (including type 2 diabetes, hypertension, and dyslipidaemia) * Eligibility for primary one-anastomosis gastric bypass (OAGB) * Provision of written informed consent Exclusion Criteria: * BMI below the defined thresholds * Severe decompensated cardiac, pulmonary, hepatic, or renal disease * Acute inflammatory conditions * Active gastric or duodenal ulcer * Psychiatric disorders or substance abuse * Pregnancy or breastfeeding * Active malignancy * Severe intra-abdominal adhesions due to prior surgery * Secondary obesity related to hypothalamic-pituitary-adrenal axis disorders

Conditions

Morbid Obesity Obesity

Locations

  • JSC "National Scientific Center of Surgery named after A.N. Syzganov" — Almaty, Kazakhstan
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record