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RECRUITING Not applicable ClinicalTrials.gov

Multimodal Laser Treatment of Photodamaged Skin

Sponsor: Merete Haedersdal • ClinicalTrials.gov ID: NCT07789002

Registry updated: 2026-09-09
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Description

The Multimodal Laser Project is a prospective, randomized, split-face clinical study investigating a novel combination of laser and light-based treatments for facial photodamage with the long-term perspective of improving skin cancer prevention. The study includes 35 patients with facial photodamage and AKs. One side of the face receives a multimodal treatment combining three complementary technologies: 1927-nm thulium laser, 1550-nm non-ablative fractional laser, and intense pulsed light (IPL), while the contralateral side serves as an untreated control. Participants are followed for 14 months to assess both clinical efficacy and longer-term preventive effects. The overall aim is not only to determine whether multimodal laser treatment improves photodamaged skin, but also to gain a deeper understanding of how the treatment affects the underlying biology of chronically sun-damaged skin and its potential role in skin cancer prevention.

Interventions

  • 1927-nm thulium laser (Device)
    Fractional non-ablative 1927-nm thulium laser treatment applied to the randomized intervention side of the face
  • 1550-nm Er:Glass laser (Device)
    Fractional non-ablative 1550-nm Er:Glass laser treatment applied to the randomized intervention side of the face
  • Intense Pulsed Light (Device)
    Intense pulsed light treatment applied to the randomized intervention side of the face

Eligibility criteria

Inclusion Criteria: * Age ≥18 years * Clinical signs of facial photodamage, including low-grade actinic keratosis (Olsen grade I-II) , solar lentigines, mottled hyper- and hypopigmentation, telangiectasia, skin thinning or atrophy, loss of skin elasticity (solar elastosis), coarse, leathery texture Exclusion Criteria: * Fitzpatrick skin type ≥ 4 * Active skin disease in the treatment area that may interfere with study treatment or assessments * Cosmetic treatments in the face within the last 12 months, including but not limited to chemical peels, injectables, and light- or laser-based treatments * Pregnancy or breastfeeding * Contraindications to the three lasers or topical anesthetics * Fitzpatrick skin type ≥ 4 * Active skin disease in the treatment area that may interfere with study treatment or assessments * Cosmetic treatments in the face within the last 12 months, including but not limited to chemical peels, injectables, and light- or laser-based treatments * Pregnancy or breastfeeding * Contraindications to the three lasers or topical anesthetics

Conditions

Photo-damage Actinic Keratosis (AK)

Locations

  • Department of Dermatology, Bispebjerg Hospital — Copenhagen NV, Denmark
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record