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RECRUITING Not applicable ClinicalTrials.gov

Non-Invasive Neurofeedback Training to Alleviate Tinnitus Distress

Sponsor: University of Illinois at Urbana-Champaign • ClinicalTrials.gov ID: NCT07788638

Registry updated: 2026-08-26
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Description

The broad goals of this project are to apply and validate the therapeutic utility of neurofeedback-guided intervention for tinnitus and its associated psychological sufferings. In this project, the investigators will evaluate whether targeted (non-auditory networks) neurofeedback-based training can restore emotional and cognitive health for individuals with bothersome tinnitus. The investigators will also link individual tinnitus scores with objective brain imaging measures before, during, and after the intervention. The investigators will accomplish these goals by using a combined brain imaging and behavioral experimental framework.

Interventions

  • neurofeedback-guided brain connectivity modulation (Behavioral)
    Real-time brain signal acquired through fMRI is used to measure ongoing functional connectivity of relevant brain regions (default mode network), and displayed to participants to mediate targeted regulation.
  • sham neurofeedback-guided brain connectivity modulation (Behavioral)
    Real-time brain signal acquired through fMRI on a different participant in the past is displayed to participants under this arm during feedback training.

Eligibility criteria

Inclusion Criteria: * Non-pulsatile tinnitus for at least 6 months, * Bothersome tinnitus, based on a Tinnitus Functional Index score \> 25, * Normal cognitive processing abilities, based on a Montreal Cognitive Assessment score\> 25. Exclusion Criteria: * Clinically diagnosed dementia or Parkinson's disease, * Meniere's disease, * Severe physical or cognitive impairments that prevent completion of study tasks or scanning, * History of drug or alcohol abuse, * History of psychological or neurological illness, except for managed anxiety or depression, * Severe chronic health problems other than hearing loss or tinnitus, * Vision that is not normal or not corrected to normal, * Unable to meet MRI clinical safety screening requirements (e.g., metal in the body, pregnancy, certain implantable devices).

Conditions

Tinnitus Aggravated Tinnitus Tinnitus, Subjective

Locations

  • Beckman Institute Biomedical Imaging Centre — Urbana, Illinois, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record