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RECRUITING Not applicable ClinicalTrials.gov

QL Block Versus EO Plane Block for Analgesia After Open Nephrectomy

Sponsor: Cairo University • ClinicalTrials.gov ID: NCT07787221

Registry updated: 2026-09-01
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Description

This prospective randomized clinical trial aims to compare two ultrasound-guided regional anesthesia techniques, the transmuscular quadratus lumborum (QL) block and the external oblique (EO) plane block, for pain relief after open nephrectomy. Open nephrectomy is a major surgical procedure that can cause significant postoperative pain and may require opioid medications for adequate pain control. Adult patients undergoing open nephrectomy at the National Cancer Institute, Cairo University, who meet the study eligibility criteria will be randomly assigned to receive either a QL block or an EO plane block before surgery. Both techniques will be performed under ultrasound guidance using bupivacaine in addition to standardized general anesthesia and multimodal postoperative analgesia. The main purpose of the study is to determine whether the QL block provides better postoperative analgesia than the EO plane block. The primary outcome will be the total amount of intravenous morphine consumed during the first 24 hours after surgery. Secondary outcomes will include postoperative pain scores, time to first request for rescue analgesia, hemodynamic changes, recovery time, patient satisfaction, and adverse effects related to analgesia or the regional anesthesia techniques. A total of 54 patients will be enrolled and randomly allocated equally between the two treatment groups.

Interventions

  • Quadratus Lumborum Block (QLB) (Procedure)
    Ultrasound-guided transmuscular quadratus lumborum block using 30 mL of 0.25% bupivacaine administered before induction of general anesthesia.
  • External Oblique Plane Block (Procedure)
    Ultrasound-guided external oblique plane block using 30 mL of 0.25% bupivacaine administered before induction of general anesthesia.

Eligibility criteria

\*\*Inclusion Criteria:\*\* * Adult patients aged 18 to 65 years. * Patients undergoing open nephrectomy at the National Cancer Institute, Cairo University. * American Society of Anesthesiologists (ASA) physical status II-III. * Body mass index (BMI) greater than 20 kg/m² and less than 35 kg/m². \*\*Exclusion Criteria:\*\* * Patient refusal to participate. * ASA physical status IV. * Age less than 18 years or greater than 65 years. * BMI less than 20 kg/m² or greater than 35 kg/m². * Known allergy or contraindication to any study medication, including local anesthetics or opioids. * History of psychiatric disorders or chronic pain. * Contraindications to regional anesthesia, including local infection at the injection site, pre-existing neuropathy, or coagulopathy. * Severe organ dysfunction, including cardiac dysfunction (ejection fraction \<40%), respiratory dysfunction (FEV1 \<50% of predicted or requirement for home oxygen therapy), hepatic dysfunction (Child-Pugh class C), or renal dysfunction (estimated glomerular filtration rate \<30 mL/min/1.73 m²).

Conditions

Postoperative Pain

Locations

  • Cairo University — Cairo, Egypt
  • Cairo University — Cairo, Egypt
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record