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Assessing the Short-Term Effects of Multi-Fiber Supplementation on Gut Health

Sponsor: Brown University • ClinicalTrials.gov ID: NCT07787026

Registry updated: 2026-08-26

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Description

This is a randomized, parallel-group interventional study evaluating the short-term gastrointestinal effects of a standardized multi-fiber supplement in healthy adults. Approximately 100 participants (50 per arm) aged 18 and older will be randomized to receive either the multi-fiber supplement or a control (flavoring agent only) daily for 10 days. Objectives include assessing effects on stool characteristics, specifically frequency and consistency, as well as changes in metagenomically inferred short-chain fatty acid production potential from the microbiota. Eligible participants must be free of chronic disease, acute illness, and recent antibiotic, probiotic, or prebiotic use. Total participation duration is 10 days.

Interventions

Prebiotic (Dietary supplement)
Formulated prebiotic supplement designed to be accessible to gut microbiota members and assist with bowel movement regularity
Placebo (Dietary supplement)
Placebo supplementation intervention, with only flavoring agents and no prebiotic fiber

Eligibility criteria

Inclusion Criteria: * in self-reported good health (i.e. no chronic disease, no acute illness) Exclusion Criteria: * chronic disease * acute illness * antibiotic, or probiotic, or prebiotic use in the prior 3 months * allergies to any of the following: psyllium husk powder, mustard, sesame, soy, tree nuts, pectin, citric acid, wheat, milk, egg, beta-glucan, barley, inulin, agave, resistant maltodextrin, arabinoxylan * adherence to any food-group strict diet (e.g. vegan, vegetarian, keto, etc.) * any of the following groups: adults unable to consent, individuals that are not yet adult, pregnant women, prisoners

Conditions

Mixed Fiber Supplementation for Healthy Adults

Locations

Biomedical Center — Providence, Rhode Island, United States

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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