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Effect of Different Volumes of SPSIP Block in Breast Surgery

Sponsor: Bursa City Hospital • ClinicalTrials.gov ID: NCT07783386

Registry updated: 2026-08-24

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Description

This randomized, double-blind study will compare the effectiveness of three different volumes of serratus posterior superior intercostal plane block for postoperative pain control in patients undergoing unilateral breast surgery with axillary lymph node dissection. Ninety participants will be randomly assigned to receive 20 mL, 30 mL, or 40 mL of 0.25% bupivacaine. The primary outcome is total tramadol consumption during the first 24 hours after surgery. Pain scores, time to first analgesic request, rescue analgesic use, quality of recovery, postoperative nausea and vomiting, block success, and block-related complications will also be evaluated.

Interventions

Bupivacaine 0.25% (20 mL) (Drug)
A single ultrasound-guided serratus posterior superior intercostal plane block will be performed before general anesthesia using 20 mL of 0.25% bupivacaine. The local anesthetic will be injected between the serratus posterior superior and intercostal muscles at the T3-T4 level.
Bupivacaine 0.25% (30 mL) (Drug)
A single ultrasound-guided serratus posterior superior intercostal plane block will be performed before general anesthesia using 30 mL of 0.25% bupivacaine. The local anesthetic will be injected between the serratus posterior superior and intercostal muscles at the T3-T4 level.
Bupivacaine 0.25% (40 mL) (Drug)
A single ultrasound-guided serratus posterior superior intercostal plane block will be performed before general anesthesia using 40 mL of 0.25% bupivacaine. The local anesthetic will be injected between the serratus posterior superior and intercostal muscles at the T3-T4 level.

Eligibility criteria

Inclusion Criteria: * Aged 18 to 75 years * American Society of Anesthesiologists physical status I-III * Scheduled for elective unilateral breast surgery under general anesthesia * Able to provide written informed consent Exclusion Criteria: * Refusal to participate * Coagulopathy * Known allergy to local anesthetics or a history of local anesthetic systemic toxicity * Liver or kidney failure * Uncontrolled diabetes mellitus * Uncontrolled hypertension * Cognitive impairment or inability to understand the study procedures * Chronic pain requiring opioid therapy * Current antidepressant use * Neuropathic pain * Infection at the block injection site * Pregnancy, suspected pregnancy, or breastfeeding * Clinically significant frailty

Conditions

Postoperative Pain

Locations

Bursa City Hospital — Nilufer, Bursa, Turkey (Türkiye)

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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