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RECRUITING Not applicable ClinicalTrials.gov

Three-Dimensional Molds Based on Radiological imagEs in Patients With Cancer: the DIRECT Trial

Sponsor: Tampere University Hospital • ClinicalTrials.gov ID: NCT07778173

Registry updated: 2026-08-21
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Description

Determination of the sites from which the histopathological samples in surgically removed lesions are collected is still done by eye by a pathologist. As radiological determination of regions of interest has already proven useful in in vivo use cases, the implementation of sampling of ex vivo lesions with the help of radiological imaging suggests great potential. By developing and implementing mold printing processes, these molds have the potential to vastly improve the accuracy and consistency of histopathological sampling and collection of tissue samples from different regions of tumor, leading to improved characterization, more individualized treatments, and eventually better survival.

Interventions

  • 3D-printed tumor mold for tissue sampling (Procedure)
    3D-printed tumor mold for tissue sampling

Eligibility criteria

Inclusion Criteria: To be eligible for the study, the study candidate must: * be willing and able to give informed consent and give their written consent for the participation in the study (in case of a child (\<15-year-old), the consent is collected in an age-appropriate manner from the study candidate and their legal guardian(s)) * have a malignant or likely malignant tumor/tumors and undergo a surgical operation. Exclusion Criteria: To be eligible for the study, the study candidate cannot: * lack the capacity to provide informed consent (if a legal guardian objects to the participation of their child (\<15-year-old), the child is not eligible); * be at risk of having their standard of care treatment jeopardized by the study, in the opinion of their physician.

Conditions

Cancer Tumor

Locations

  • Tampere University Hospital — Tampere, Finland
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record