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RECRUITING Not applicable ClinicalTrials.gov

The Effect of 5-hydroxytryptophan on ADHD Traits and Eye Movements

Sponsor: University of Sheffield • ClinicalTrials.gov ID: NCT07777328

Registry updated: 2026-08-20
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Description

The aim of this project is to look at the impact of 5-Hydroxytryptophan (5-HTP) on distractibility. 5-HTP is the precursor to the neurotransmitter serotonin and is a chemical that the body produces naturally. There is evidence that distractibility is associated with a decreased level of serotonin. This research aims to see if giving people 5-HTP will alter their distractibility, which will form part of an initial assessment as to whether 5-HTP could be used to support people with attention problems. The study involves completing a short survey about mental health and behaviours, and if eligible, participation in an in-person study at the University of Sheffield. The in-person session involves completing some cognitive tasks to look at eye movement, taking 5-HTP or a sugar tablet with no active ingredients, and then completing the tasks again after a 90-minute wait.

Interventions

  • 5-hydroxytryptophan (food supplement) 200mg (Dietary supplement)
    200mg 5-HTP delivered in two tablets. Tablets obtained from Nature's Best supplements. Each tablet contains 3982mg of Griffonia seed extract, providing 100mg of 5-HTP. The tablets consist of calcium carbonate, griffonia seed extract, Anti-caking Agents (Silicon Dioxide, Stearic Acid, \& Magnesium Stearate) and Tablet Coating (Hydroxypropyl Methylcellulose, Glycerol).
  • 5-hydroxytryptophan (food supplement) 300mg (Dietary supplement)
    300mg 5-HTP delivered in three tablets. Tablets obtained from Nature's Best supplements. Each tablet contains 3982mg of Griffonia seed extract, providing 100mg of 5-HTP. The tablets consist of calcium carbonate, griffonia seed extract, Anti-caking Agents (Silicon Dioxide, Stearic Acid, \& Magnesium Stearate) and Tablet Coating (Hydroxypropyl Methylcellulose, Glycerol).
  • Placebo (Other)
    Unmedicated lactose-sucrose tablets provided by Ainsworth's homoeopathic remedies

Eligibility criteria

Inclusion Criteria: * 18-65 years of age * Normal or corrected to normal vision with contact lenses. * Score of \<9 or \>14 on the ASRS v5 (assessed in pre screen questionnaire) Exclusion Criteria: * Current use of psychostimulant medication or medication for the treatment of ADHD * Current use of medications known to impact the serotonergic system (e.g., SSRIs). * Smoking or vaping * Pregnancy * Breast feeding * Lactose intolerance * Veganism * Dyslexia

Conditions

Attention Deficit and Hyperactivity Disorder (ADHD) Attention Deficit Hyperactivity Disorder in Adults Attention Deficits

Locations

  • University of Sheffield — Sheffield, South Yorkshire, United Kingdom
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record