A Study of Raludotatug Deruxtecan With or Without Bevacizumab as First-Line Maintenance Treatment in Non-HRD-Positive Advanced Ovarian Cancer (MK-5909-006, (ENGOT-ov102/GOG-3141/ REJOICE-Ovarian 04)
Sponsor: Merck Sharp & Dohme LLC • ClinicalTrials.gov ID: NCT07776691
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Researchers are looking for new ways to treat ovarian cancer (OC). Current treatment for OC may start with surgery to remove as much of the cancer as possible. After surgery, people may receive chemotherapy. After chemotherapy, standard care options may include: Maintenance treatment, which is used after another therapy to keep the cancer from growing, spreading, or coming back. Bevacizumab is a targeted therapy used as standard maintenance treatment. Targeted therapy works to control how specific types of cancer cells grow and spread. Observation, which is watching to see if cancer grows or worsens. The study medicine, raludotatug deruxtecan- R-DXd, is a targeted therapy. The goal of this study is to learn if people who receive R-DXd maintenance treatment with or without bevacizumab live longer without the cancer getting worse than people who receive standard care.
Interventions
-
R-DXd
(Biological)
R-DXd administered as an intravenously (IV) infusion
-
Bevacizumab
(Drug)
Administered as an intravenously IV infusion
Eligibility criteria
Conditions
Locations
- MedStar Washington Hospital Center ( Site 0026) — Washington D.C., District of Columbia, United States
- Texas Oncology - DFW ( Site 8005) — Fort Worth, Texas, United States
- Rambam Health Care Campus ( Site 1402) — Haifa, Israel
- Sourasky Medical Center ( Site 1403) — Tel Aviv, Israel
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Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
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