RECRUITING Not applicable ClinicalTrials.gov

Real-time Opioid Study

Sponsor: Yale University • ClinicalTrials.gov ID: NCT07768007

Registry updated: 2026-09-14

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Description

This feasibility study collects initial data on the use of an fMRI neurofeedback protocol for treating anhedonia in methadone-treated individuals with opioid use disorder (OUD). The intervention tested has previously been shown to reduce anhedonia in individuals with depression and this study is collecting first-in-human data in an OUD population. Investigators will assess tolerability of the intervention and collect preliminary data from 2-3 subjects monitoring changes in anhedonia, non-substance-related autobiographical memory recall, and meaning in life.

Interventions

real-time functional magnetic resonance imaging (rt-fMRI) neurofeedback (Device)
A non-invasive, non-pharmacological therapeutic tool that enables an individual to learn to modulate their neural activity in order to effect behavioral change.

Eligibility criteria

Inclusion Criteria: * ≥3 months of methadone treatment for OUD * Presence of anhedonia, as assessed via SHAPS * Room for improvement in specific autobiographical memory recall, as assessed via AMT Exclusion Criteria: * Failure to pass an MRI screening * Women who are pregnant * Psychosis, as assessed via Yale PRIME Early Psychosis Screening Test * Serious suicidal ideation * Serious medical condition * Legally blind

Conditions

Substance Use Disorder (SUD)

Locations

APT Foundation — New Haven, Connecticut, United States

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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