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RECRUITING Not applicable ClinicalTrials.gov

Effects of Flavonoid Foods on Carbonyl Stress

Sponsor: North Carolina Agriculture & Technical State University • ClinicalTrials.gov ID: NCT07767149

Registry updated: 2026-08-24
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Description

This randomized crossover study will compare low- and high-flavonoid diets in healthy adults to identify flavonoid-derived biomarkers in urine and plasma. Using targeted liquid chromatography-mass spectrometry (LC-MS) metabolomics, researchers will measure known and novel flavonoid metabolites and evaluate whether a higher flavonoid intake reduces carbonyl stress markers, including reactive carbonyl species (RCS) and advanced glycation end products (AGEs).

Interventions

  • High-Flavonoid Diet (Dietary supplement)
    Participants will consume the high-flavonoid diet daily for 3 weeks. The diet includes 1 Red Delicious apple (approximately 160 g), freeze-dried whole blueberry powder (25 g), soy milk (240 mL), and decaffeinated Lipton green tea ( 2 g tea leaves), providing approximately 420 mg flavonoids per day.
  • Low-Flavonoid Diet (Dietary supplement)
    Participants will consume the low-flavonoid diet daily for 3 weeks. The diet includes 1/3 of Red Delicious, 107 g of pineapple; 8.3 g of blueberry powder plus 16.7 g of blueberry placebo powder; 80 mL of soy milk plus 160 mL of 2% low-fat milk; and 0.67 g tea leaves, providing approximately 140 mg flavonoids per day.

Eligibility criteria

Inclusion Criteria: * Age 25-70 years * BMI between 18 and 30 * Have no known allergy to test food * Have no known allergies to green tea, apples, blueberries, soy milk, or pineapples * Be not engaging in high-intensity exercise * Having blood and urine clinical tests in the normal range. * Be not taking antibiotics for six months * Be not currently taking medication * No taking any prescription drugs * All flavonoid-enriched supplements should be avoided. The flavonoid-enriched supplements list includes soy isoflavones, Lipo-Flavonoid, Citrus Bioflavonoids Complex, Super Flavonoids, Super Antioxidants, Quercetin Supplement, Essential-C, flavonoids, and milk thistle. Also other flavonoid supplements, including but not limited to luteolin, Rutin, etc. * No drugs or supplements within three weeks of the experiment * Be nonsmoking * Have no alcoholic intoxication * No alcoholic addiction * \< 3-4 drinks per week (less than 2 glasses (300 mL) per drink) * No alcohol within three weeks of the experiment * Have no extended exposure to industrial wastes Exclusion Criteria: * Disease: gout, heart disease, peripheral vascular disease, degenerative kidney, degenerative liver, diabetes, GI disorders, or endocrine disorders * Cancer patients * Currently diagnosed cancer patients will be excluded. * Medication-free for \>2 years could be considered.

Conditions

Human Health Flavonoids Carbonyl Stress

Locations

  • North Carolina Agriculture and Technical State University/ NRI Building — Kannapolis, North Carolina, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record