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RECRUITING Not applicable ClinicalTrials.gov

The Effect of Olive Leaf Extract Supplementation on Training-induced Skeletal Muscle Functional and Molecular Adaptations in Healthy Volunteers

Sponsor: University of Lausanne • ClinicalTrials.gov ID: NCT07729072

Registry updated: 2026-10-08
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Description

The goal of this study is to investigate the effect of combining olive leaf extract supplementation with endurance training (moderate intensity continuous training or sprint interval training). We hypothesize that OLE supplementation during training, as compared to training alone with placebo, will translate into better performance outcomes. More specifically, we hypothesize that the additional benefits of OLE supplementation on performance will be mediated by improved mitochondrial characteristics in skeletal muscle and increased neural activation.

Interventions

  • Olive leaf extract (Dietary supplement)
    A capsule containing 250 mg of an olive leaf extract preparation will be swallowed with a glass of water daily for 21 days.
  • Placebo (Dietary supplement)
    A capsule containing 336 mg of cellulose microcrystalline will be swallowed with a glass of water daily for 21 days.

Eligibility criteria

Inclusion Criteria: 1. Being between 18 and 45 years old 2. Being healthy (assessed through the PAR-Q questionnaire). 3. Being physically active, but not involved in any structured training program 4. Being available for the study period. Exclusion Criteria: 1. If a participant answers positively to any YES/NO question in the PAR-Q health questionnaire. For questions requiring a precision, any positive answer will be reviewed by a medical doctor, who will determine the inclusion/exclusion of the participant. 2. Having allergy to xylocaine 3. Being pregnant.

Conditions

Healthy Adult Participants Exercise Training Neuromuscular Adaptations Nutritional Intervention

Locations

  • Bâtiment Synathlon, quartier UNIL-Centre — Lausanne, Switzerland
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record