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RECRUITING Phase 3 ClinicalTrials.gov

AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight

Sponsor: Novo Nordisk A/S • ClinicalTrials.gov ID: NCT07720271

Registry updated: 2026-09-28
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Description

The purpose of this clinical study is to find out if zenagamtide is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as oral tablets once a day. Participants will either get zenagamtide (the treatment being tested) or Placebo (treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Interventions

  • zenagamtide (Drug)
    zenagamtide will be taken orally.
  • Placebo (Drug)
    Placebo matched to zenagamtide will be taken orally.

Eligibility criteria

Inclusion Criteria: * Male or female (sex at birth). * Age 18 and older (both inclusive) at time of signing the informed consent. Exclusion Criteria: * Glycated haemoglobin (HbA1c) more than or equal to (≥) 6.5% \[48 millimoles per mole (mmol/mol)\] as measured by the central laboratory at screening. * History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records. * Treatment with glucagon-like peptide-1 (GLP-1) receptor agonists (RA), dual GLP-1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment) or amylin analogues before screening.

Conditions

Overweight Obesity

Locations

  • Pinnacle Research Group LLC — Anniston, Alabama, United States
  • Univ of Alabama Birmingham — Birmingham, Alabama, United States
  • Chambliss Clinical Trials LLC — Montgomery, Alabama, United States
  • Providence Medical Foundation — Fullerton, California, United States
  • Torrance Clinical Research Institute, Inc. — Lomita, California, United States
  • Diablo Clinical Research, Inc. — Walnut Creek, California, United States
  • Univ of Colorado at Denver — Aurora, Colorado, United States
  • Brain Matters Research — Delray Beach, Florida, United States
  • Northeast Research Institute — Fleming Island, Florida, United States
  • Miguel Rebollar PA — Hialeah, Florida, United States
  • Jacksonville Ctr Clin Res — Jacksonville, Florida, United States
  • South Broward Research LLC — Miramar, Florida, United States
  • Clinical Neuroscience Solution — Orlando, Florida, United States
  • Florida Institute for Clinical Research, LLC — Orlando, Florida, United States
  • Oviedo Medical Research, LLC — Oviedo, Florida, United States
  • Hope Clin Res & Wellness — Conyers, Georgia, United States
  • East West Medical Research Institute_Honolulu — Honolulu, Hawaii, United States
  • Great Lakes Clinical Trials — Chicago, Illinois, United States
  • Clinical Investigation Spec Gurnee — Gurnee, Illinois, United States
  • Endeavor Health — Skokie, Illinois, United States
  • Evanston Premier Hlthcr Res — Skokie, Illinois, United States
  • Midwest Inst For Clin Res — Indianapolis, Indiana, United States
  • Northern Pines Hlth Ctr, PC — Buckley, Michigan, United States
  • StudyMetrix Research LLC — City of Saint Peters, Missouri, United States
  • Palm Research Center Inc. — Las Vegas, Nevada, United States
  • Comprehensive Weight Ctrl Prog — New York, New York, United States
  • Medication Mgmnt, LLC_Grnsboro — Greensboro, North Carolina, United States
  • Accellacare of Raleigh — Raleigh, North Carolina, United States
  • Accellacare-Salisbury PMG Res — Salisbury, North Carolina, United States
  • Accellacare and KDCILM, LLC — Wilmington, North Carolina, United States
  • Lynn Institute of Norman — Norman, Oklahoma, United States
  • Clinical Res Collaborative — Cumberland, Rhode Island, United States
  • Medical Uni of SC Charleston — Charleston, South Carolina, United States
  • Coastal Carolina Research Ctr — North Charleston, South Carolina, United States
  • Hillcrest Clinical Research — Simpsonville, South Carolina, United States
  • Spartanburg Medical Research — Spartanburg, South Carolina, United States
  • Amarillo Medical Specialists — Amarillo, Texas, United States
  • North Texas Endocrine Center — Dallas, Texas, United States
  • Washington Cntr Weight Mgmt — Arlington, Virginia, United States
  • Health Res of Hampton Roads — Newport News, Virginia, United States
  • National Clin Res Inc. — Richmond, Virginia, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record