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QLESP Block for Pain Control in Robotic Partial Nephrectomy

Sponsor: Huazhong University of Science and Technology • ClinicalTrials.gov ID: NCT07704970

Registry updated: 2026-09-25

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Description

The goal of this clinical trial is to learn if an ultrasound-guided nerve block called QLESP works to reduce pain and the need for strong pain medicines after robotic kidney surgery in adults. The main questions it aims to answer are: 1. Does QLESP reduce the total amount of opioid pain medicine participants need in the first 48 hours after surgery? 2. Does QLESP lower pain scores and improve recovery quality after surgery? Researchers will compare participants who receive QLESP block to participants who receive the same numbing medicine injected only at the surgical wound sites. Participants will: 1. Be randomly assigned to receive either QLESP or local wound injection before surgery. 2. Have a patient-controlled pain pump for 48 hours after surgery. 3. Complete pain scores and recovery quality questionnaires at 2, 6, 12, 24, 48, and 72 hours after surgery. 4. Be followed until hospital discharge.

Interventions

ropivacaine (local infiltration) (Drug)
Ultrasound-guided QLESP block with 30 mL of 0.375% ropivacaine (15 mL injected between the erector spinae muscle and the transverse process at L2 level, followed by 15 mL injected between the quadratus lumborum and psoas major muscles) after induction of general anesthesia.
ropivacaine (Drug)
Local wound infiltration with 30 mL of 0.375% ropivacaine at the port sites performed by the surgeon at the end of surgery.

Eligibility criteria

Inclusion Criteria: * Aged 18 to 75 years * Scheduled for elective robot-assisted partial nephrectomy (RAPN) * American Society of Anesthesiologists (ASA) physical status I to III * Body mass index (BMI) 18 to 35 kg/m² * Voluntarily signed informed consent form Able to understand pain scoring and use of patient-controlled analgesia (PCA) Exclusion Criteria: * Language, communication, or comprehension barriers * Infection at the intended puncture site * Coagulopathy or bleeding diathesis * Known allergy or contraindication to local anesthetics or opioids * Use of analgesic medications within the past 3 months * Peripheral neuropathy * Severe cardiac, hepatic, or renal dysfunction * Pregnancy or breastfeeding * Refusal to participate in the study

Conditions

Renal Cell Carcinoma (Kidney Cancer) Postoperative Pain Nerve Block

Locations

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei, China

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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