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RECRUITING Not applicable ClinicalTrials.gov

NASA Exercise Prebreathe Study

Sponsor: Duke University • ClinicalTrials.gov ID: NCT07702539

Registry updated: 2026-10-05
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Description

This study evaluates oxygen prebreathe protocols and exercise conditions to reduce risk of decompression sickness during simulated extravehicular activity. Healthy adult volunteers will undergo oxygen prebreathe followed by hypobaric chamber exposure with monitoring for symptoms and ultrasound detection of bubbles.

Interventions

  • Oxygen Prebreathe and Hypobaric Exposure (Procedure)
    Prebreathe 100% oxygen followed by simulated spacewalk conditions in hypobaric chamber with exercise protocols.

Eligibility criteria

Inclusion Criteria: * Non-smoking volunteers aged 30-60 years * Able to meet VO2 peak requirements (\>35 ml/kg/min males, \>30 ml/kg/min females) Exclusion Criteria: * Pregnancy * Lung disease, heart disease, hypertension, or diabetes * Musculoskeletal pain conditions * Requirement for regular medications such as analgesics

Conditions

Decompression Sickness

Locations

  • Duke University Medical Center — Durham, North Carolina, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record