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RECRUITING Phase 4 ClinicalTrials.gov

Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia

Sponsor: General Hospital of Ningxia Medical University • ClinicalTrials.gov ID: NCT07670923

Registry updated: 2026-08-19
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Description

At the initiation of induction for non-intubated general anesthesia, ciprofol or propofol will be administered intravenously at a rate of 10 mL/min. The Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale will be used to evaluate sedation depth. This study aims to assess the effects of ciprofol and propofol on hemodynamics and respiratory function in elderly patients undergoing non-intubated general anesthesia.

Interventions

  • Propofol Injection (Drug)
    Intravenous administration, injection rate of 10 ml/min, continuous and uniform infusion until the patient's MOAA/S sedation score is ≤1 point. This is used for the induction of general anesthesia in short-duration medical procedures for elderly individuals aged 65-80 without intubation and with spontaneous respiration
  • Ciprofol Injection (Drug)
    Intravenous administration, injection rate of 10 ml/min, continuous and uniform infusion until the patient's MOAA/S sedation score is ≤1 point. This is used for the induction of general anesthesia in short-duration medical procedures for elderly individuals aged 65-80 without intubation and with spontaneous respiration

Eligibility criteria

Inclusion Criteria: 1. Patients scheduled for elective non-intubated general anesthesia 2. Age ranging from 65 to 80 years old 3. American Society of Anesthesiologists (ASA) physical status class I-III 4. Written informed consent signed by the patient or legal guardian Exclusion Criteria: 1. Confirmed allergy to propofol, ciprofol or their excipients 2. Severe cardiovascular diseases (uncontrolled hypertension, heart failure, severe arrhythmia, etc.) 3. Severe respiratory diseases (chronic obstructive pulmonary disease, obstructive sleep apnea syndrome, etc.) 4. Severe hepatic or renal insufficiency 5. Long-term regular use of sedatives or opioids 6. Baseline bradycardia (HR \< 50 beats/min) or hypoxemia (SpO₂ \< 90%)

Conditions

Comparison of Hemodynamics and Respiratory Function Between Ciprofol and Propofol in Elderly Patients Undergoing Non-intubated General Anesthesia

Locations

  • Cardiovascular and Cerebrovascular Disease Hospital, General Hospital of Ningxia Medical University — Yinchuan, Ningxia, China
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record