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RECRUITING Not applicable ClinicalTrials.gov

Health Ahead Comparative Effectiveness Study

Sponsor: William Brandenburg, MD • ClinicalTrials.gov ID: NCT07669168

Registry updated: 2026-09-08
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Description

The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening system deployable in any environment, including the most isolated and resource-limited communities. Each change is isolated as a single variable against current practice, and every comparison is evaluated with a common set of engagement, behavior-change, experience, cost, and longitudinal outcome measures, so results accumulate on a consistent yardstick across the life of the platform. The first comparison evaluates AI-assisted versus human-only interpretation ("reads") of screening data. Subsequent pre-planned comparisons, added by protocol amendment, evaluate static versus interactive personalized report delivery; mobile community versus fixed laboratory screening; and a hybrid medical-droid-plus-human delivery model versus human-only screening.

Interventions

  • AI-Assisted Screening Interpretation (AI Reads) (Behavioral)
    An AI-generated read of the acquired screening battery is produced and presented to the physician of record as a clinical aid. All models used are third-party models, executed unmodified on Longevity Metrics clinical infrastructure. The physician reviews each read, records a structured judgment before sign-off, and then produces and signs the released interpretation, which may adopt, modify, or reject any read.
  • Human-Only Screening Interpretation (Behavioral)
    All acquired screening data, images, tracings, and laboratory results are interpreted by the physician of record and qualified clinical staff under physician supervision, by standard practice and without AI decision support. This is the current standard of care and the active comparator.

Eligibility criteria

Inclusion Criteria: * Age 18 years or older * Willing and able to provide written informed consent, or enrollment with consent of a legally authorized representative * Willing to participate in longitudinal follow-up. Exclusion Criteria: \- Age under 18 years.

Conditions

Health Services Accessibility Rural Health Medically Underserved Area Preventive Health Services Patient Participation Health Behavior Aging Cardiovascular Diseases Metabolic Syndrome Cognitive Dysfunction Frailty Activities of Daily Living Health Related Quality of Life Health Equity Telemedicine

Locations

  • Longevity Metrics — Boulder, Colorado, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record