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RECRUITING Phase 1 ClinicalTrials.gov

A Study of LY4174794 in Participants With Obesity or Overweight Who Are Otherwise Healthy

Sponsor: Eli Lilly and Company • ClinicalTrials.gov ID: NCT07654972

Registry updated: 2026-10-15
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Description

The main purpose of this study is to understand how safe and well-tolerated LY4174794 is in participants with obesity or overweight who are otherwise healthy. Blood tests will be performed to check how much LY4174794 gets into the bloodstream and how long it takes the body to eliminate it. Participation in this study will last about 30 to 39 weeks (7 to 10 months).

Interventions

  • LY4174794 (Drug)
    Administered SC.
  • LY4174794 (Drug)
    Administered IV.
  • Placebo (Drug)
    Administered SC.

Eligibility criteria

Inclusion Criteria: * Are overtly healthy with no comorbidities related to body mass index (BMI), such as type 2 diabetes mellitus or unstable cardiovascular disease * Are overweight with a BMI of ≥27 kilogram per meter square (kg/m²), or have obesity with a BMI of ≥30 kg/ m² * Have had a self-reported stable weight for 3 months prior to screening Exclusion Criteria: * Have a history or presence of cardiovascular, respiratory, hepatic, renal, GI, endocrine, hematological, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs, or of constituting a risk when taking the study intervention, or of interfering with the interpretation of data * Is an individual of childbearing potential (IOCBP)

Conditions

Obesity Overweight

Locations

  • ICON Early Phase Services, LLC — San Antonio, Texas, United States
  • ICON Early Phase Services, LLC — Salt Lake City, Utah, United States
  • Lilly Centre for Clinical Pharmacology — Singapore, Singapore
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record