Fluorescent Probe for Assessment of Renal Elimination

Description

Accurate measures of kidney function is important for precision dosing of many medications. The current methods of determining kidney function largely hinge on the use of equations that use common laboratory values such as serum creatinine \& static variables like age \& weight. These are helpful for trending over time, but often are inaccurate during times of medical illness. Other more accurate methods of measuring kidney function include urine collection, although this is not commonly used because of various reasons that make the collection inconvenient or unreliable. The new transdermal glomerular filtration (tGFR) device permits accurate, real-time evaluation of kidney function. This novel method has not been rigorously compared with urine collection \& other methods of determining kidney function in hospitalized patients. The goal of the study is to compare tGFR with other accepted methods of determining kidney function.

Interventions

• Relmapirazin (Drug)
  IV push of relmapirazin (Lumitrace) prior to use of the tGFR device
• Iohexol (Drug)
  Small IV push bolus of iohexol as a probe for renal function will be administered prior to use of the tGFR device.
• Medibeacon tGFR monitor (Device)
  The tGFR monitor will be applied to the patient after relmapirazin bolus for measurement of GFR.
• Urine creatinine clearance collection (Diagnostic test)
  8-hour urine creatinine clearance collection will be performed during the study period to compare to tGFR \& other renal function measures.

Eligibility criteria

Conditions

Locations

• UKHealthCare/University of Kentucky — Lexington, Kentucky, United States