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A Home-Based Exercise Intervention (CAREFit-BMT) in Improving Heart Function Among Patients With High Risk Acute Myeloid Leukemia Undergoing Stem Cell Transplant

Sponsor: University of Washington • ClinicalTrials.gov ID: NCT07616921

Registry updated: 2026-09-11
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Description

This clinical trial studies how well a home-based exercise intervention called Cardiorespiratory Fitness in Bone Marrow Transplant Program (CAREFit-BMT) works in improving heart function among patients with high risk acute myeloid leukemia (AML) undergoing stem cell transplant. Older adults and those with other medical conditions are at a higher risk for complications in the heart and blood vessels (cardiovascular). Older age at transplantation has been associated with nearly all cardiovascular complications occurring after stem cell transplant. This is likely explained by the structural and functional changes that occur in aging hearts as well as the larger burden of cardiovascular risk factors such as diabetes, high blood pressure, and obesity. CAREFit-BMT is a "prehabilitation" program, or exercise initiated prior to intensive therapy, that consists of aerobic exercises and strength training. CAREFit-BMT may be able to increase the likelihood of safe and successful transition to stem cell transplant in patients with high risk AML.

Interventions

  • Aerobic Exercise (Other)
    Undergo moderate-intensity aerobic exercises
  • Resistance Training (Other)
    Undergo strength training
  • Biospecimen Collection (Procedure)
    Undergo collection of blood
  • Electronic Health Record Review (Other)
    Ancillary studies
  • Survey Administration (Other)
    Ancillary studies
  • Interview (Other)
    Ancillary studies

Eligibility criteria

Inclusion Criteria: * Age 18 years or older * Ability to understand and willingness to sign a written informed consent document * New diagnosis of acute myeloid leukemia at Fred Hutch * High-risk patients as defined by one, or more, of the following criteria: * Age 65 years or older and/or * Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI) score ≥ 3 (for patients 20 years old or older) and/or * CARE-BMT score ≥ 5 * Note: HCT-CI and CARE-BMT scores will be measured at pre-screening by study staff * Able to exercise at low to moderate intensity, as evaluated by study staff * Access to a mobile smart phone * Able to read and write in English Exclusion Criteria: * Orthopedic, neurologic, or other problems that prevent safe ambulation and protocol adherence. Information on prior falls and other recent orthopedic or neurologic problems will be used to make judgment about protocol eligibility * Recurrence of AML or diagnosis of other invasive cancer * Severe anemia (hemoglobin \< 7 gm/dl) * History of severe aortic stenosis * New York Heart Association (NYHA) class IV heart failure * Severe pain with basic movement * Pregnant persons * Unable to give consent

Conditions

Acute Myeloid Leukemia

Locations

  • Fred Hutch/University of Washington Cancer Consortium — Seattle, Washington, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record