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RECRUITING Phase 1 ClinicalTrials.gov

A Study to Assess the Effect of Empasiprubart on Nerve Morphology by Ultrasound in Adults With Multifocal Motor Neuropathy

Sponsor: argenx • ClinicalTrials.gov ID: NCT07610564

Registry updated: 2026-09-24
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Description

The main purpose of the study is to evaluate empasiprubart use in adults living with Multifocal Motor Neuropathy (MMN). The researchers will evaluate the effect of empasiprubart on the thickness of the nerves, muscle strength, movement, and on the potential improvement of grip strength of the participants in handling objects. The study consists of an open-label treatment period where all participants will receive empasiprubart intravenously (IV). After the last dose of empasiprubart participants will enter a safety follow-up period for up to 15 months. The total study duration for each participant will be approximately 29 months. More information can be found here: clinicaltrials.argenx.com/empasound

Interventions

  • Empasiprubart IV (Biological)
    Intravenous infusions of empasiprubart

Eligibility criteria

Inclusion Criteria: * Is at least 18 years old * Diagnosed with MMN * Has an MMN-RODS centile score of ≤90 * Has confirmed nerve thickening in at least 1 nerve per ultrasound measurement Exclusion Criteria: * Besides the indication under study, known autoimmune disease or any medical condition that, in the investigator's opinion, would interfere with an accurate assessment of clinical symptoms of MMN or puts the participant at undue risk.

Conditions

Multifocal Motor Neuropathy (MMN)

Locations

  • Pineo Medical Ecosystem — Tbilisi, K'alak'i T'bilisi, Georgia
  • Aversi Clinic LTD — Tbilisi, Georgia
  • Jo Ann Medical Center — Tbilisi, Georgia
  • S. Khechinashvili University Clinic, Ltd. — Tbilisi, Georgia
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record