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Embolosclerotherapy Versus Deep Dorsal Vein Revascularization in Venogenic Erectile Dysfunction

Sponsor: Mansoura University Hospital • ClinicalTrials.gov ID: NCT07604194

Registry updated: 2026-10-16

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Description

Venous leakage is one of the causes of erectile dysfunction and can be managed using different treatment modalities, including surgical ligation and percutaneous embolization. This randomized clinical trial aims to evaluate and compare the efficacy, durability, safety, side effects, and complications of two treatment procedures-embolosclerotherapy of the periprostatic plexus and deep dorsal vein revascularization-in the management of erectile dysfunction caused by venous leak.

Interventions

Endovascular embolosclerotherapy (Procedure)
The goal of endovascular therapy is to achieve adequate embolization of efferent pelvic veins, including the periprostatic and internal or external pudendal veins.
Revacularization of deep dorsal vein (Procedure)
Penile venous arterialization of the Deep Dorsal vein using inferior epigastric artery

Eligibility criteria

Inclusion Criteria: * Cases with ED reporting difficulty in attaining or maintaining erection for at least 6 months. * All participants were sexually active, in a stable and heterosexual partnership, living with their sexual partner for at least the past one year, and have only one sexual partner. * The frequency of trying sexual intercourse was ≥1/week. * Unsatisfactory response to PDE5i medication. * All cases suffered venogenic erectile dysfunction diagnosed by color flow Doppler sonography before and after intracavernous injection of vasoactive drugs or Dynamic infusion cavernosometry-cavernosography (selected cases), which indicated veno-occlusive dysfunction. Exclusion Criteria: * Refusal to participate. * Major psychological or psychiatric disorders. * Non-vascular causes of ED including penile anatomic defects, any related neurological etiology or spinal cord injury, hypogonadism and hormonal disturbances. * History of previous venous surgery, suspected or proven deep venous thrombosis, history of Deep Vein Thrombosis.

Conditions

Erectile Dysfunction Due to Venous Disorder Erectile Dysfunction (ED)

Locations

Mansoura University hospital — Al Mansurah, Dakahlia Governorate, Egypt

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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