RECRUITING Not applicable ClinicalTrials.gov

Music for Pain and Dementia

Sponsor: Yale University • ClinicalTrials.gov ID: NCT07602283

Registry updated: 2026-09-21

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Description

This study aims to provide mechanistic insights into how group drumming as a music-based intervention (MBI) affects pain responses and nociceptive function in individuals with Alzheimer's Disease (AD), mild dementia or mild cognitive impairment (MCI). Heart rate (HR), heart rate variability (HRV), and brain activity will be measured during communal drumming with their dyadic partners and others. Brain activity, blood pressure, cognitive abilities, blood hormone levels, and static and dynamic pain will also be measured during sessions pre and post the 8-week community drum circle. Investigators will leverage various measurement techniques including, but not limited to, electroencephalography (EEG), quantitative sensory testing (QST), behavioral, surveys, and physiological monitoring to study the impact of group drumming on pain and brain activity in AD and inter-dyad synchrony.

Interventions

Drumming session (Behavioral)
A 45-minute to 1-hour group drumming session
Music-listening session (Behavioral)
A 45-minute to 1-hour group music-listening session

Eligibility criteria

Inclusion Criteria: * Clinical Dementia Rating 0.5 - 2 * Be a person with or caregiver to a person with a diagnosis of early Alzheimer's Disease, mild dementia, and/or mild cognitive impairment (MCI) and chronic pain defined as non-cancer pain lasting \>3 months that occurs most days and limits life or work activities OR Be a caregiver to a person with a diagnosis of early Alzheimer's Disease, mild dementia, and/or mild cognitive impairment (MCI) and chronic pain defined as non-cancer pain lasting \>3 months that occurs most days and limits life or work activities * Able to provide informed consent * Willing to wear an EEG headset and heart rate monitoring devices * Willing to answer survey questions about topics related to the study * Willing to be audio / video recorded * Willing to undergo QST, blood draw, heart rate data collection and cognitive testing Exclusion Criteria: * Clinical Dementia Rating \<0.5 or \> 2 * Unable to provide informed consent * Endorsing suicidal ideation (SI), self-injurious behavior, or homicidal ideation (HI) above the threshold defined in the "Risk Reduction and Safety Plan" * Participating in another clinical trial studying AD and/or Dementia * Starting a new prescription medication in the last 4 weeks * Taking central nervous system acting medications that may interfere with study measurements as determined at PI discretion

Conditions

Alzheimer Disease Dementia Mild Cognitive Impairment Peer-bonded Caregiver Caregiver

Locations

Connecticut Mental Health Clinic — New Haven, Connecticut, United States

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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

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