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RECRUITING Phase 2 ClinicalTrials.gov

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

Sponsor: Eli Lilly and Company • ClinicalTrials.gov ID: NCT07589608

Registry updated: 2026-10-08
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Description

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.

Interventions

  • Macupatide (Drug)
    Administered SC
  • Eloralintide (Drug)
    Administered SC
  • Placebo (Drug)
    Administered SC

Eligibility criteria

Inclusion Criteria: * See Master Protocol CWMM (NCT06143956) for inclusion criteria Exclusion Criteria: In addition to exclusion criteria in Master Protocol CWMM (NCT06143956): * Have type 1 diabetes or type 2 diabetes * Have an ongoing history of bradyarrhythmia and/or sinus bradycardia * Have an elevated resting pulse rate (greater than 100 bpm) or reduced resting pulse rate (less than 60 bpm) * Have a history of acute or chronic pancreatitis * All concomitant medications should be at a stable dose for at least 3 months prior to screening

Conditions

Overweight Obesity

Locations

  • The Institute for Liver Health II dba Arizona Clinical Trials - Mesa — Chandler, Arizona, United States
  • Headlands Research - Scottsdale — Scottsdale, Arizona, United States
  • The Institute for Liver Health II dba Arizona Liver Health-Tucson — Tucson, Arizona, United States
  • NorCal Medical Research, Inc — Greenbrae, California, United States
  • Velocity Clinical Research, Huntington Park — Huntington Park, California, United States
  • Peninsula Research Associates — Rolling Hills Estates, California, United States
  • Diablo Clinical Research, Inc. — Walnut Creek, California, United States
  • Stamford Therapeutics Consortium — Stamford, Connecticut, United States
  • New Horizon Research Center — Miami, Florida, United States
  • Indago Research & Health Center, Inc — Miami Lakes, Florida, United States
  • Suncoast Clinical Research, Inc. — New Port Richey, Florida, United States
  • Charter Research - Winter Park — Orlando, Florida, United States
  • Charter Research - Lady Lake — The Villages, Florida, United States
  • Medical Research Partners — Ammon, Idaho, United States
  • Great Lakes Clinical Trials - Ravenswood — Chicago, Illinois, United States
  • Cotton O'Neil Diabetes & Endocrinology — Topeka, Kansas, United States
  • Monroe Biomedical Research - Louisville — Louisville, Kentucky, United States
  • Knownwell — Needham, Massachusetts, United States
  • Lucida Clinical Trials — New Bedford, Massachusetts, United States
  • Headlands Research - Detroit — Southfield, Michigan, United States
  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division — Troy, Michigan, United States
  • StudyMetrix Research — City of Saint Peters, Missouri, United States
  • Clinvest Headlands Llc — Springfield, Missouri, United States
  • Las Vegas Medical Research — Las Vegas, Nevada, United States
  • Dent Neurologic Institute — Amherst, New York, United States
  • Rochester Clinical Research, LLC — Rochester, New York, United States
  • Medication Management — Greensboro, North Carolina, United States
  • Monroe Biomedical Research — Monroe, North Carolina, United States
  • Lucas Research, Inc — Morehead City, North Carolina, United States
  • Lucas Research, Inc. — New Bern, North Carolina, United States
  • CTI Clinical Research Center — Cincinnati, Ohio, United States
  • Tribe Clinical Research, LLC — Greenville, South Carolina, United States
  • Quality Medical Research — Nashville, Tennessee, United States
  • IMA Clinical Research Austin — Austin, Texas, United States
  • FutureSearch Trials of Dallas — Dallas, Texas, United States
  • PlanIt Research, PLLC — Houston, Texas, United States
  • Endeavor Clinical Trials — San Antonio, Texas, United States
  • Texas Valley Clinical Research — Weslaco, Texas, United States
  • Sovah Clinical Research-River District — Danville, Virginia, United States
  • Central Washington Health Services Association d/b/a Confluence Health — Wenatchee, Washington, United States
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Official Source

Data sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

View Official Record